摘要
呫吨染料是一类重要荧光染料,其良好的光物理性质使其得到了广泛应用。呫吨染料一般通过富电子的间苯二酚(或间氨基苯酚)与邻苯二甲酸酐在酸催化条件下缩合得到。近年来,呫吨染料在生物显微成像领域获得广泛应用,染料结构也日趋复杂,传统的合成方法不能满足需要,因而不断有新的呫吨染料合成方法见诸文献。本文简要概述了既有呫吨染料合成路线,并分析讨论了各方法的优缺点及适用底物范围。
Xanthene dyes are a series of brilliant fluorescent dyes exhibiting superior photophysical properties, which facilitate their applications in various field. Traditionally, they are prepared via acid-catalyzed condensations between electron-rich resorcinol （m-aminophenols） and phthalic anhydride. Recently, structurally complicated xanthenes are often in need for bioimaging applications and not readily accessed with the aforementioned methods. This has promoted the development of novel pathways for their synthesis, which are summarized in this review. The scope and limitations of each methods are briefly discussed.
出处
《应用化学》
CSCD
北大核心
2017年第12期1403-1412,共10页
Chinese Journal of Applied Chemistry
基金
国家自然科学基金(21372080
21572061)资助~~
关键词
呫吨
合成
荧光染料
分子探针
xanthene
synthesis
fluorophores
molecular probes
