摘要
目的研究宫颈锥形切除术治疗宫颈上皮内瘤变(CIN,不包括原位癌)伴高危型人乳头瘤病毒(HR-HPV)感染患者术后HPV感染消除情况,探讨影响术后HR-HPV转阴因素及宫颈环行电圈切除术(LEEP术)在治疗CIN的同时治疗HR-HPV感染的疗效.方法采用HCⅡ法检测120例CIN伴HR-HPV阳性患者LEEP锥切术后3,6,9,12个月HR-HPV感染情况,观察术后HR-HPV持续感染及清除率的变化情况,同时评价及分析可能影响术后HR-HPV持续感染的因素.结果术前存在HR-HPV感染的CIN患者宫颈LEEP术治疗后,术后3,6,9,12个月HR-HPV持续感染率为35.83%,34.17%,29.17%及11.67%;HR-HPV的持续感染,术后清除率与术前HRHPV病毒的高负荷量(>500 RLU/CO)呈正相关,与患者的病变级别无相关性,术前HR-HPV负荷量>500 RLU/CO者术后HPV持续感染率明显高于术前HR-HPV负荷量<500 RLU/CO者(P<0.05),且术前HR-HPV负荷量>500 RLU/CO者术后HPV清除速率明显低于术前HR-HPV负荷量<500 RLU/CO者(P<0.05).结论 LEEP术是清除伴有CIN改变的HR-HPV感染的有效方法,对HR-HPV病毒负荷量的降低有一定作用.
Objective The aim of this study was to study the cervical conization treatment for cervical intraepithelial neoplasia （ CIN, not including carcinoma in situ ） with high-risk human papilloma virus （ HR-HPV） infection in patients with postoperative HPV infection,factors influencing the positive postoperative HR-HPV infection to negative, and investigate the curative effect of cervical circular electric lap resection （ loop electrosurgical excision procedure,LEEP） on CIN and HR-HPV infection at the same time. Method HCⅡmethod was used to detect the HR-HPV infection in 120 patients who had undergone CIN and with positive HR-HPV infection 3,6,9 and 12 months after LEEP,to observe the postoperative persistent infection and clearance, and at the same time,to evaluate and analyze the related factors affecting the postoperative persistent HR-HPV infection. Results The HR-HPV infection rate in CIN patients with the preoperative HR-HPV infection 3,6,9 and 12 months after the treatment of LEEP was 35 . 83%, 34 . 17%, 29 . 17% and 11 . 67%, respectively;thepersistent HR-HPV infection and the postoperative clearance were positively correlated with the high preoperative HR-HPV virus load （〉500 RLU/CO）,and not correlated with the patients＇ lesion levels. The postoperative persistent HPV infection rate of patients whose preoperative HR HPV-load was ＆gt;500 RLU/CO was significantly higher than that of patients whose preoperative HR-HPV-load was 〈500 RLU/CO（P〈0. 05）,and the clearance of patients whose preoperative HR-HPV load was 〉500 RLU/CO postoperative HPV was significantly lower than that of patients whose preoperative HR HPV-load was 〈500 RLU/CO （P〈0. 05）. Conclusion LEEP is an effective method to clear the HR-HPV infection with CIN;the preoperative HR HPV load more than 500 RlU/CO company is one of the main risk factors to affect the turning of positive infection to negative infection,which is not correlated with the patient＆#39; s lesion levels,and the cervical LEEP has a certain e
出处
《北华大学学报（自然科学版）》
CAS
2017年第5期649-651,共3页
Journal of Beihua University（Natural Science）
基金
吉林省科技发展计划项目(2014180)
关键词
高危型人乳头瘤病毒
持续感染
清除率
宫颈LEEP术
high-risk human papilloma virus
persistent infection
clearance
cervical LEEP operation
