摘要
恶性肿瘤一直为严重威胁人类健康的重大疾病之一,随着当前社会生活习惯、饮食、生活环境等因素改变,恶性肿瘤的发病也发生了显著改变。以肥胖、糖尿病/高血糖、高血脂症、高血压等代谢异常的集合--MetS已成为诱发多种重大疾病高危风险因素。越来越多的研究证实,多种恶性肿瘤的发生与MetS有关,MetS与恶性肿瘤已成为威胁人类健康的全球性问题受到关注。近年来,基础医学和流行病学关于MetS诱发恶性肿瘤深入研究更进一步明确MetS与恶肿瘤之间存在内在密切联系,MetS各个因素之间相互关联,单个因素的累加增加肿瘤的发病风险及死亡率。随着深入研究,其相关分子机制被逐步发现,MetS多种风险因素之间协同累加诱发恶性肿瘤风险及分子机制更为明确,可能机制包括:长期高血糖作用、肥胖和高血脂,胰岛素因子作用以及内分泌因子干扰物等多方面因素协调作用,临床上针对肿瘤预防和治疗手段也相应的逐步改善。本文将围绕近年来相关研究,从流行病学、发病机制方面综述MetS与恶性肿瘤的关联。
Malignant tumor has been a major diseases threat to human health, with current social habits, diet, living environment and other factors changing, the incidence of malignant tumors have also undergone significant changes. The set of diabetes/hyperglycemia, hyperlipidemia and hypertension, which is obesity, has been a risk factor for many kinds of major diseases. A growing number of studies confirmed that a variety of malignant tumor associated with MetS, MetS and malignant tumor have been a global problem threatened human health. In recent years, the further researche of basic medical sciences and epidemiology on MetS-induced malignant tumor clarified the intimate relationship between MetS and malignancy, each factor of MetS is interrelated, the accumulation of individual factors increased the risk of cancer and mortality. With further research, the molecular mechanisms are gradually discovered, the molecular mechanism which accumulation of risk factors induced tumor is more explicit, possible mechanisms include： the role of long-term hyperglycemia, obesity and hyperlipidemia, the role of insulin factor and secretion factor interferences which coordinate the action, and the prevention and treatment in clinical of tumor is also gradually improved. This review will describe the association between metabolic syndrome and malignant tumor from the points of the epidemiology and molecular mechanism based on recent years related research.
出处
《肿瘤代谢与营养电子杂志》
2017年第3期343-348,共6页
Electronic Journal of Metabolism and Nutrition of Cancer
基金
军队保健专项课题(12BJZ14)
广西桂林市科技计划课题(20150126-2-3)
关键词
代谢综合征
恶性肿瘤
肥胖
糖尿病
高血脂
高血压
Metabolic syndrome
Malignant neoplasms
Obesity
Diabetes
Hyperlipidemia
Hypertension
