摘要
目的探讨细菌性阴道病(BV)、外阴阴道假丝酵母菌病(VVC)和细胞溶解性阴道病(CV)之间阴道代谢物的差异性。方法纳入2014年3至10月在西安高新医院门诊就诊的186例女性,其中BV女性50例,VVC女性41例,CV女性30例和健康女性65例;测定阴道分泌物中D-乳酸和L-乳酸、细胞外基质金属蛋白酶诱导因子(EMMPRIN)和基质金属蛋白酶-8(MMP-8)浓度,并分析其与三种阴道疾病的关系。结果四组阴道分泌物L-乳酸、D-乳酸、EMMPRIN、MMP-8浓度均有显著性差异(F值分别为917.059、727.342、133.657、262.906,均P<0.05),BV组阴道分泌物D-乳酸和L-乳酸浓度与对照组和VVC组相比显著性减少(t值分别为15.624、80.106;26.299、87.663,均P<0.05),VVC组阴道分泌物中L-乳酸浓度与对照组相似(t=1.423,P>0.05)。对照组、BV组和CV组女性阴道分泌物中EMMPRIN浓度相似,对照组和BV组女性阴道分泌物中MMP-8浓度相似(t=1.296,P>0.05)。对照组、BV组、VVC组和CV组阴道分泌物中EMMPRIN和L-乳酸浓度高度相关(r值分别为0.501、0.629、0.374、0.671,均P<0.05)。BV组阴道分泌物中EMMPRIN和D-乳酸浓度呈高度相关(r=0.311,P<0.05),而对照组、VVC组和CV组阴道分泌物中EMMPRIN和D-乳酸浓度则弱相关。对照组和VVC组阴道分泌物中EMMPRIN和MMP-8浓度高度相关(r值分别为0.462、0.519,均P<0.001)。结论 BV女性阴道分泌物D-乳酸和L-乳酸分泌不足,而VVC女性的EMMPRIN和MMP-8水平提升,女性在L-乳酸水平提升;这些偏差可能为预防和治疗BV、VVC和CV提供新的手段。
Objective To investigate the difference in vaginal metabolites among women with bacterial vaginosis（BV）,vulvovaginal candidiasis（VVC）and cytolytic vaginosis（CV）.Methods A total of 186 women visiting outpatient department of Xi＇an Hi-tech Hospital were enrolled in this study,including 50 women with BV,41 women with VVC,30 women with CV and 65 healthy women as controls.Concentrations of D-lactic acid,L-lactic acid,extracellular matrix metalloproteinase inducer（EMMPRIN）and matrix metalloproteinase-8（MMP-8）in vaginal secretions were detected and their relation with three kinds of vaginal diseases was analyzed.Results There were significant differences in concentrations of L-lactic acid,D-lactic acid,EMMPRIN and MMP-8 in vaginal secretions in 4 groups（Fvalue was 917.059,727.342,133.657 and 262.906,respectively,all P〈0.05）.Concentrations of D-lactic acid and L-lactic acid in vaginal secretions in BV group were significantly lower than those in the control group and VVC group（t value was 15.624,80.106,26.299 and 87.663,respectively,all P〈0.05）.L-lactic acid concentration in vaginal secretions in VVC group was similar to that in the control group（t=1.423,P〈0.05）.Concentrations of EMMPRIN in vaginal secretions in the control group,BV group and CV group were similar,and concentrations of MMP-8 in vaginal secretions in the control group and BV group were similar（t=1.296,P〈0.05）.Concentrations of EMMPRIN were highly correlated with L-lactic acid in vaginal secretions in the control group,BV group,VVC group and CV group（r value was 0.501,0.629,0.374 and 0.671,respectively,all P〈0.05）.Concentrations of EMMPRIN were also closely related with D-lactic acid in vaginal secretions in BV group（r=0.311,P〈0.05）,whereas those were weakly correlated with D-lactic acid in vaginal secretions in the control group,VVC group and CV group.Concentrations of EMMPRIN and MMP-8 in vaginal secretions in the control group and VVC group were highly correlated（r value was 0.462 and 0.519,res
出处
《中国妇幼健康研究》
2017年第11期1371-1374,共4页
Chinese Journal of Woman and Child Health Research
