摘要
目的研究早产儿维生素D营养状况,并探讨相关影响因素。方法回顾性分析2011年7月-2015年10月入住南京医科大学附属无锡妇幼保健院新生儿病房的早产儿血清25(OH)D水平,以及早产儿胎龄、性别、分娩方式、出生季节、出生体重,母亲年龄、职业、婚姻状况、体质指数、受孕方式、胎产次、妊娠期并发症(包括产前发热、妊娠期高血压、妊娠期糖尿病、妊娠期肝内胆汁淤积症、胎儿生长受限)及产前激素使用情况等潜在影响。纳入同期住院的97例足月儿作为对照病例。结果早产儿组血清25(OH)D平均水平为(36.81±16.64)nmol/L,足月儿组血清25(OH)D平均水平为(40.49±12.75)nmol/L,早产儿组显著低于足月儿组(t=-2.45,P=0.02);早产儿组维生素D严重缺乏、缺乏、不足和充足的比例分别为26.00%、53.20%、16.40%、4.30%,足月儿分别为0、76.30%、21.60%和2.10%,差异有统计学意义(Z=-3.88,P<0.01)。维生素D缺乏组早产儿母亲的年龄大于偏低组(t=2.15,P=0.03),缺乏组的母亲体质指数小于偏低组(t=7.74,P<0.01),缺乏组的血钙含量低于偏低组(t=-2.31,P=0.02)。夏秋季节出生早产儿维生素D营养状况好于冬春季节(χ~2=6.83,P=0.01)。Logistic回归分析结果示:母亲年龄(OR=1.28,95%CI:1.19~1.37,P<0.01)、母亲BMI(OR=0.82,95%CI:0.75~0.89,P<0.01)、冬春季节出生(OR=0.57,95%CI:0.33~0.97,P=0.04)为早产儿维生素D缺乏的危险因素。结论早产儿维生素D缺乏发生率较高;母亲年龄、体质指数及冬春季节出生是早产儿维生素D缺乏的危险因素。
Objective To study the vitamin D nutrition status and its influencing factors in preterm infants.Methods The data of serum 25（OH）D level in preterm infants admitted in Wuxi Maternity and Child Health Hospital Affiliated to Nanjing Medical University during the period of July 2011 to October 2015 was retrospectively analyzed.Analysis was also conducted on the influence of gestational age,gender,delivery mode,birth season,birth weight,age,occupation,marriage status and body mass index of mother,reproductive technology,parity,pregnancy complications（including prenatal fever,gestational hypertension,gestational diabetes,intrahepatic cholestasis of pregnancy and fetal growth retardation）as well as prenatal hormone administration.There were 97 full-term infants recruited in control group.Results Mean serum 25（OH）D level was 36.81±16.84 nmol/Land 40.49±12.75 nmol/L in preterm infants group and full-term infants group,respectively,and that in preterm infants group was significantly lower than that in full-term infants group（t=-2.45,P=0.02）.In preterm infants group the proportion of cases with severe vitamin D deficiency,deficiency,insufficiency and sufficiency was 26.00%,53.20%,16.40% and 4.30%,respectively,and in full-term infants group that was 0,76.30%,21.60% and 2.10%,respectively.The difference was statistically significant（Z=-3.88,P〈0.01）.Age of mother was significantly older in vitamin D deficiency group than that in vitamin D insufficient group（t=2.15,P=0.03）,body mass index of mother was lower（t=7.74,P〈0.01）and serum calcium level of preterm infants was lower（t=-2.31,P=0.02）.Vitamin D nutrition status of preterm infants born in summer and autumn was better than that of those born in winter and spring（χ~2=6.83,P=0.01）.Logistic regression analysis showed that age of mother（OR=1.28,95%CI：1.19-1.37,P〈0.01）,body mass index of mother（OR=0.82,95%CI：0.75-0.89,P〈0.01）,and born in winter and spring（OR=0.57,95%CI：0.33-0.97,P=0.04）were high risk factors of vit
出处
《中国妇幼健康研究》
2017年第11期1337-1340,共4页
Chinese Journal of Woman and Child Health Research
基金
江苏省卫计委妇幼保健科研项目(No.F201427)
无锡市"科教强卫工程"医学重点学科(锡卫科教[2017]6号)
南京医科大学附属无锡妇幼保健院青年项目(No.2014Q13)
关键词
早产儿
足月儿
维生素D
危险因素
preterm infants
full-term infants
vitamin D
risk factor
