摘要
目的观察恩替卡韦治疗乙肝后肝硬化失代偿期的疗效及不良反应。方法选取80例乙肝后肝硬化失代偿期患者为研究对象，采用随机数字表法将患者分为两组，对照组给予常规治疗，观察组在常规治疗基础上加用恩替卡韦治疗。观察比较两组乙肝病毒脱氧核糖核酸（HBV—DNA）变化情况、肝功能指标变化情况、不良反应发生率。结果治疗前，观察组和对照组HBV—DNA、丙氨酸转氨酶（ALT）和天冬氨酸转氨酶（AST）水平差异无统计学意义（P〉0．05）；治疗4周、12周、24周及48周后，观察组与对照组HBV．DNA、ALT和AST水平均较治疗前显著降低（均P〈0．05）；且观察组各指标明显优于对照组（均P〈0．01）。观察组不良反应发生率（17．5％）明显低于对照组（40．0％），差异有统计学意义（X2=8．345，P〈0．05）。结论采用恩替卡韦治疗乙肝后肝硬化失代偿期患者，可以有效降低患者HBV—DNA的表达水平，改善肝功能，疗效显著，且无明显的不良反应。
Objective To explore the efficacy and adverse effects of entecavir in the treatment of decompen- sate cirrhosis patients with chronic hepatitis B. Methods 80 decompensate cirrhosis patients with chronic hepatitis B were selected as the research subjects. The patients were randomly divided into two groups according to the digital table. The control group was given conventional treatment, and the observation group was treated with entecavir on the basis of conventional treatment. The hepatitis B virus deoxyribonucleic acid （ HBV - DNA） changes, the changes of liver function, the incidence of adverse reactions were compared between the two groups~ Results Before treatment, the HBV - DNA, ALT and AST levels had no significant differences between the two groups （ all P 〉 0.05 ）. After treatment for 4,12,24 and 48 weeks, the levels of HBV - DNA, ALT and AST of the observation group and the control group were significantly lower than those before treatment （ all P 〈 0.05 ）, which of the observation group were significantly lower than those of the control group （ all P 〈 0.05 ）. The incidence rate of adverse reaction of the observation group was 17.5%, which was significantly lower than 40.0% of the control group, the difference was statistically significant （ x2 = 8.345,P 〈 0.05 ）. Conclusion The entecavir can effectively reduce the level of HBV - DNA, improve liver function and without significant adverse effects in treating decompensate cirrhosis patients with chronic hepatitis B.
出处
《中国基层医药》
CAS
2017年第24期3701-3704,共4页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省自然科学基金项目（Y16H310016）
关键词
肝硬化
肝炎
乙型
慢性
恩替卡韦
Liver cirrhosis
Hepatitis B, chronic
Entecavir
