摘要
为了探讨细胞毒性T淋巴细胞相关抗原4（cytotoxic T lymphocyte-associated antigen-4, CTLA-4）基因多态性与青海省藏族Graves眼病（Graves′ ophthalmopathy，GO）的相关性。本组选择了2013年6月至2016年11月在青海省人民医院确诊的藏族Graves病（GD）患者130例作为观察对象，将130例GD患者分为GO组（71例）和无眼病GD组（59例），采用限制性片段长度多态性聚合酶链反应（PCR-RFLP）方法，检测观察对象血清中CTLA-4基因外显子1＋49位A/G基因型及等位基因频率。CTLA-4基因外显子1＋49位A/G基因型（AA、AG、GG）频率在在GO组与无眼病GD组比较差异有统计学意义。
To investigate the association of the gene polymorphism of cytotoxic T lymphocyte-associated antigen-4 （CTLA-4）with Graves′ ophthalmopathy（GO）in Qinghai Tibetans. 130 case of Graves′ disease（GD）were selected from June 2013 to November 2016 in The People′s Hospital of Qinghai Province. These patients were assigned into 2 groups, GO（n=71）and GD without GO（n=59）. The genotypes and alleles of CTLA-4 gene were detected by polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）. Distribution of CTLA-4 exon 1（＋ 49A/G）genotype frequencies（AA, AG, and GG）was different between 2 groups.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2017年第11期962-964,共3页
Chinese Journal of Endocrinology and Metabolism
基金
青海省科技厅课题项目（2014-ZJ-769）
