摘要
脂蛋白肾病是一种罕见的肾脏疾病,主要病理特点为明显扩张的肾小球毛细血管襻,腔内脂蛋白栓子形成,免疫荧光或免疫组织化学染色提示载脂蛋白B(Apo B)或Apo E阳性,伴有明显的血清Apo E浓度升高。罕见的Apo E基因变异可能导致脂蛋白肾病。该文介绍了脂蛋白肾病的流行病学、发病机制、临床特点、病理特点和治疗相关的研究进展。
Lipoprotein glomerulopathy is a rare renal disease,mainly pathologically characterized by enlarged glomerular capillaries and intraglomerular lipoprotein thrombosis. Immunofluorescent or immunohistochemical staining yields positive results of apolipoprotein B( Apo B) or Apo E,accompanied by significant elevation of serum Apo E concentration. Apo E gene mutation is probably the cause of lipoprotein glomerulopathy.In this article,we summarized recent research progress upon the epidemiology,pathogenesis,clinical and pathological characteristics,treatment of lipoprotein glomerulopathy.
出处
《新医学》
2017年第12期825-828,共4页
Journal of New Medicine
基金
广东省科技计划产学研合作项目(2016A090922005)
关键词
脂蛋白肾病
载脂蛋白E
基因突变
Lipoprotein glomerulopathy
Apolipoprotein E
Gene mutation
