摘要
目的探讨腹腔镜下卵巢巧克力囊肿剥除术后辅以不同药物治疗对患者性激素及预后的影响效果,并进行比较,探讨最佳治疗措施。方法选择我科2014年7月~2016年7月收治的126例卵巢巧克力囊肿患者,随机分为A组(予以达菲林治疗)、B组(予以孕三烯酮),C组(予以米非司酮),每组各42例。在治疗前(术前月经来潮第3d)、后(术后药物治疗结束后首次月经第3d)采用放射免疫法检测患者的性激素水平,并进行疗效以及复发率的判定。结果 A组的有效率为97.62%,复发率为2.38%,B组的分别为95.24%、4.76%,C组的分别为97.62%、9.52%,与A组比较,C组患者的复发率升高明显,差异具统计学意义(P<0.05)。A、B组与B、C组复发率、有效率比较,差异无统计学意义(P>0.05);治疗前,各组患者的性激素水平各指标比较,差异无统计学意义(P>0.05);组内治疗前后比较,与治疗前比较,治疗后各组患者的性激素水平各指标比较,差异具统计学意义(P<0.05,P<0.01);组间比较,治疗后,与A组E2水平比较,B、C组均升高明显,差异具统计学意义(P<0.05),其余指标,各组比较,差异无统计学意义(P>0.05)。结论腹腔镜剥除卵巢巧克力囊肿术后联合不同药物均能够抑制残余病灶复发,疗效较好,但达菲林的复发率更低。
Objective To investigate the effect of different drugs on the sex hormone and prognosis of patients after enucleation of ovarian chocolate cyst, and to compare and explore the best treatment measures. Methods 126 cases of ovary chocolate cyst were selected as research objects, and randomly divided into group A （adopted Diphereline）, group B （adopted gestrinone） and group C （adopted mifepristone）, 42 cases in each group. Sex hormone level of patients were detected by radioimmunoassay Before （before operation menstrual onset 3rd day） and after （after the end of medicine treatment, first menstrual onset 3rd day）, and the curative effect and recurrence rate were determined. Results The effective rate of group A was 97.62%, the recurrence rate was 2.38%, and those of group B were 95.24% and 4.76% respectively, and those of group C were 97.62% and 9.52% respectively. Compared with group A, the recurrence rate of group C was significantly increased, the difference was statistically significant （P 〈 0.05）. There was no significant difference in recurrence rate and effective rate between group A, group B and group B and group C（P ~ 0.05）. Before the treatment, comparing the index of sex hormone levels of patients in each group, there was no significant difference（P 〉 0.05）; compared with before treatment, the difference of index of sex hormone levels of patients in each group after treatment was significantly different（P 〈 0.05, P 〈 0.01）; Comparison between groups after treatment, compared with the E2 level of group A, group B and C were increased significantly, the difference was statistically significant（P 〈 0.05）, there were no significant differences in other indexes between groups（P 〉 0.05）. Conclusion Laparoscopic enucleation of ovarian chocolate cyst after surgery combined with different drugs are able to suppress the residual recurrence, the curative effect is good, but the Diphereline recurrence rate is lower.
作者
李强
LI Qiang(Department of Gynaecology and Obstetrics, the Hospital of Traditional Chinese Medicine of Taizhou City, Taizhou 225300, Chin)
出处
《中国医药科学》
2017年第22期19-22,共4页
China Medicine And Pharmacy
关键词
卵巢巧克力囊肿
腹腔镜术后
疗效
西药
性激素
Chocolate cyst ovary
After gynaecological laparoscopy
Curative effect
Curative effect
Western medicine
Sex hormones
