摘要
多药耐药（MDR）是临床药物抗癌失败的重要原因之一，涉及多种机制。其中，P-糖蛋白（P-gp）介导的经典MDR机制与MDR的形成关系密切，通过“药泵”效应排出细胞内化疗药物，显著降低化疗疗效。姜黄素主要提取自中药姜黄的地下根茎，具有广泛的药理活性。近年研究发现，姜黄素通过调控多种信号通路，抑制P-gp的功能和表达，发挥逆转肿瘤MDR的作用。
Multidrug resistance （MDR） is one of the important reasons for the failure of clinical anti- cancer drugs, involving multiple mechanisms. Among them, the classical MDR mechanism mediated by P-gly- coprotein （P-gp） is closely related to the formation of MDR, which can excrete intracellular chemotherapeutic drugs through the ＂drug pump＂ effect and significantly reduce the therapeutic effect. Curcumin is mainly ex- tracted from the underground rhizome of Chinese medicine turmeric, with a wide range of pharmacological activity. Recent studies have found that curcumin also has a role in reversing the MDR of the tumor, by inhibi- ting both P-gp function and expression, and this process involves a variety of signal paths.
出处
《国际肿瘤学杂志》
CAS
2017年第10期758-761,共4页
Journal of International Oncology
基金
湖北省卫生计生委青年人才项目（WJ2017H0036）
关键词
姜黄素
P糖蛋白
多药耐药
信号通路
Curcumin
P-glycoprotein
Multidrug resistance
Signal path
