摘要
目的探讨自身免疫性甲状腺疾病(Autoimmune Thyroid Disease,AITD)与女性不孕不育的关系。方法通过比较607例不孕不育女性(实验组)和205例体检正常女性(对照组)血清中的促甲状腺激素(thyroid stimulating hormone,TSH)和甲状腺过氧化物酶抗体(Thyroid Peroxidase antibody,TPOAb)水平,并进行logistic相关性分析,用以判断TPOAb及TSH水平与临床不孕不育的关系。结果实验组TPOAb较对照组升高,差异有统计学意义(P<0.01),而实验组TSH较对照组比较,差异无统计学意义(P>0.05)。TPOAb的Wald值为4.501(P<0.05),OR值为1.328,说明TPOAb是女性不孕不育的独立危险因子。结论妇女不孕不育与血清内TPOAb水平存在一定的关系。TPOAb可作为育龄妇女不孕不育病因的检测指标。
Objective To investigate the relationship between AITD with female infertility. Methods Compared the serum revels of TSH and TPOAb in 607 infertile female patients （experimental group） and 205 normal health women （control group）, and analyzed the result by logistic regression analysis, then to judg the relationship between TPOAb and TSH with female infertility. Results The level of TPOAb in experimental group was higher than the control group, the differences was statically significant （P〈0.01）.While the level of TSH was not different between them （P〉0.05）. The Wald of TPOAb was 4.50l（P〈0.05）, the OR was 1.328, the results showed that TPOAb was the independent risk factor of female infertility. Conclusion Female infertility was associated with serum TPOAb levels, TPOAb can be a marker to predict female infertility risk.
作者
阳剑
李攀
YANG Jian;LI Pane(Clinical Cytogenetics Laboratory, Maternal and Child Health Care Hospital, Baoding Hebei 071000, China;Clinical Laboratory, Eastern Hospital, Baoding First Central Hospital, Baoding Hebei 071000, China)
出处
《中国继续医学教育》
2017年第26期76-78,共3页
China Continuing Medical Education
