摘要
目的研究不同剂量艾司奥美拉唑联合铋剂四联疗法对幽门螺杆菌(Hp)阳性十二指肠溃疡的临床疗效。方法选取2017年1~8月我院消化科门诊确诊的Hp阳性十二指肠溃疡活动期患者68例,随机分为对照组与研究组,各34例。在给予两组患者胶体果胶铋胶囊+阿莫西林胶囊+克拉霉素分散片基础上,再给予不同剂量艾司奥美拉唑镁肠溶片,疗程10 d,10 d后给予相同剂量艾司奥美拉唑镁肠溶片继续治疗4周。比较治疗后两组患者溃疡的愈合情况、Hp根除率及不良反应发生率。结果两组治疗溃疡的总有效率分别为94.1%、97.1%,两组比较差异无统计学意义(P>0.05),但研究组与对照组显效率分别为79.4%、61.8%,Hp根除率分别为91.2%、82.4%,研究组显效率及Hp根除率明显高于对照组(P<0.05),两组不良反应发生率均为5.9%,差异无统计学意义(P>0.05)。结论大剂量艾司奥美拉唑联合铋剂四联疗法能提高Hp根除率,有效促进十二指肠溃疡的愈合。
Objective To study the clinical efficacy of different doses of esomeprazol combined with bismuth quadruple therapy on helicobacter pylori（Hp） -positive duodenal ulcer. Methods 68 patients with Hp - positive duodenal ulcer in the active period diagnosed in the gastroenterology clinic from January 2017 to August 2017 were randomly divided in- to control group （n=34） and study group （n=34）. The two groups were treated with different doses of esomeprazole magnesium enteric-coated tablets based on colloidal pectin bismuth capsules ＋ amoxicillin capsules＋ clarithromycin dispersible tablets, and course was 10 days. After 10 days, the same dose of esomeprazole magnesium enteric-coated tablets was given 4 weeks of continuous treatment. The ulcer healing, Hp eradication rate and the incidence of adverse reactions between the two groups were compared after treatment. Results The effective rates of the two groups were 94.1% and 97.1%, respectively. There was no significant difference（P〉0.05）.The effective rate of the study group and the control group were 79.4% and 61.8% respectively. And the Hp eradication rates in the two groups were 91.2% and 82.4%（P〈0.05）.The effective rate and the Hp eradication rate were significantly higher than those of the control group （P〈0.05）.The incidence of adverse reactions in the two groups was 5.9%, and there was no significant difference （P〉 0.05）. Conclusion High dose of esomeprazol combined with bismuth quadruple therapy can improve Hp eradication rate and promote the healing of duodenal ulcer effectively.
作者
王澍琴
薄艳萍
苏爱平
王学玲
WANG Shuqin BO Yanping SU Aiping WANG Xueling(Department of Internal Medicine, Department of Clinical Medicine, Fenyang College, Shanxi Medical University, Fenyang 032200, China Department of Gastroenterology, Fenyang Hospital in Shanxi Province, Fenyang 032200,China)
出处
《中国现代医生》
2017年第32期103-105,共3页
China Modern Doctor
基金
山西省卫生计生委科研课题(201602049)
