摘要
目的讨论成年体检人群血浆中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase-associated lipocalin,NGAL)的表达水平,并探讨年龄、性别以及疾病状态对其表达是否有影响。方法收集符合入组标准的996例入院体检者一般资料以及血浆样本,采用双抗体夹心酶联免疫吸附法测定血浆NGAL水平。按照不同年龄、性别及疾病分组,对比不同年龄段、性别、疾病间血浆NGAL表达水平是否存在差异,并对血浆NGAL的影响因素进行多因素线性回归分析。结果 Pearson相关分析显示,血浆NGAL水平与年龄、空腹血糖、血肌酐、内生肌酐清除率均呈正相关(P<0.05)。按疾病分组后,高血压组、空腹血糖受损(IFG)和(或)2型糖尿病组、血脂异常组血浆NGAL值与对应的正常组比较,差异均有统计学意义(P<0.05)。多因素线性回归分析显示,老年、男性、高血压、IFG和(或)2型糖尿病、血脂异常为血浆NGAL水平的影响因素(P<0.05)。结论成年人群的血浆NGAL水平相对稳定,老年、男性、年龄>65岁、高血压、IFG和(或)2型糖尿病、血脂异常为影响NGAL表达的因素。
Objective To detect the plasma level of neutrophil gelatinase-associated lipocalin（ NGAL） in adult outpatients,and to investigate the influencing factors. Methods General informations of 996 adults receiving physical healthy examination were collected,and the plasma level of NGAL was determined by double-antibody sandwich enzyme-linked immunosorbent assay. All subjects were grouped by age,sex and disease condition. And the plasma levels of NGAL were compared in different groups.The influencing factors of plasma NGAL were analyzed by multifactorial linear regression. Results Pearson correlation analysis showed that plasma level of NGAL was positively correlated with age,fasting plasma glucose,serum creatinine、endogenous creatinine clearance rate（ P〈0. 05）. The expressions of plasma NGAL also showed significant differences in adults with hypertension,impaired fasting glucose（ IFG） and（ or） type 2 diabetes and dyslipidemia when compared with the corresponding normal groups（ P〈0. 05）. Multifactorial linear regression analysis showed that gender,age,hypertension,IFG and（ or）type 2 diabetes,dyslipidemia significantly affected plasma NGAL. Conclusions The levels of plasma NGAL is relatively stable. Male,aged 65 years,hypertension,IFG and（ or） type 2 diabetes and dyslipidemia are the independent factors influencing the expression of NGAL in adults.
出处
《实用老年医学》
CAS
2017年第11期1046-1049,共4页
Practical Geriatrics
