摘要
目的:探讨胃壁细胞抗体在多发性硬化中的临床意义。方法:采用间接免疫荧光法检测壁细胞抗体、水通道蛋白-4抗体;回顾性分析32例多发性硬化患者患者的临床资料。结果:32例患者血清中均无水通道蛋白-4抗体。10份(31.25%)血清样本壁细胞抗体阳性。壁细胞抗体阳性患者平均功能残障评分为(2.85±0.97)分,平均脊髓病变长度为(5.8±7.4)个节段;9例有脊髓病变,其中7例有核磁共振强化病灶、7例抗内皮细胞抗体阳性、4例有甲状腺疾病。上述指标均高于血清学阴性的多发性硬化患者(P<0.05)。血清学阴性的患者脑部磁共振强化病灶以及广泛脑部病灶的发生率更高(P<0.05)。结论:水通道蛋白-4抗体阴性的多发性硬化患者中可出现胃壁细胞抗体,胃壁细胞抗体阳性的多发性硬化具有一定的临床意义。
Objective：To investigate the clinical significance of parietal cell antibody （ PCA） in multiple sclerosis （ MS ） . Methods： The PCA and aquaporin-4 antibody （ AQP4 ） were detected by indirect immunofluorescence. The clinical data of 32 MS patients were retrospectively analyzed. Results：None of the 32 patients had AQP4. 10 （31.25%） of the serum samples were PCA-positive. Of the PCA-positive patients,the mean EDSS score was 2. 85 ± 0. 97, and the mean length of spinal lesions was 5. 8 ± 7. 45 segments. Nine of 10 patients had spinal lesions,including 7 with GAD-enhancing lesions,7 positive for anti-endothelial cell antibody and 4 with thyroid disorder. These indicators were higher than those in seronegative MS patients （ P〈0.05） . Brain GAD-enhancing lesions and extensive brain lesions were more prevalent sero-negative patients （ P〈0. 05 ） . Conclusion：PCA may be present in AQP4-negative MS patients. Positivity of PCA may have a clinical role in multiple sclerosis.
出处
《广州医科大学学报》
2017年第3期15-18,共4页
Academic Journal of Guangzhou Medical University
基金
广东省自然科学基金项目(2014A030313499)
