摘要
近年来随着二代基因测序技术的成熟、成本下降、耗时减少,使其得以广泛服务于医学。人们对疾病的认识有了一个新的高度。这已使部分人群受益。例如发现乳腺癌易感基因BRCA1、BRCA2,肺癌相关的TP53、KRAS、EGFR,大肠癌中的KRAS等。这些有助于疾病的早期预警及诊断,并可设计个体化的治疗方案,提高生存率的同时减少不良反应。但并非所患者都这么幸运。
Head and neck squamous cell carcinoma,HNSCC,has high morbidity and mortality.Even in America,more than 1/2 to 2/3 patients have been diagnosed at advanced stage.So,its urgent to find ways to diagnose HNSCC earlier and foresee the curative effect.With the achievement of Next-Generation Sequencing,researchers are trying to develop early diagnostic technology from a new perspective,such as personal genomics,proteomics,metabolomics and other related personal information.Here we reviewed the recent research in early diagnosis of HNSCC.
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2017年第22期1770-1774,共5页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
关键词
头颈鳞状细胞癌
早期诊断
预后
精准医疗
新进展
head and neck squamous cell carcinoma
early stage diagnosis
prognosis
precision medicine
recent advances
