摘要
目的观察急性重症胰腺炎患者应用HA330血液灌洗的临床效果。方法选取2015-04-25—2017-04-24某院收治的急性重症胰腺炎患者90例,根据治疗方法的不同分为两组,应用常规西医治疗的47例患者为常规组,在常规西医治疗基础上给予血液灌洗治疗的43例患者为研究组。观察两组患者治疗后的炎症因子水平和免疫功能。结果研究组患者治疗后的hs-CRP、IL-6、IL-8和TNF-α的水平分别为(0.69±0.44)mg/L、(4.57±1.16)pg/m L、(10.02±1.23)pg/m L和(7.56±2.08)pg/m L,CD4^+和CD4^+/CD8^+的水平分别为(42.54±8.75)%和2.10±0.78,常规组患者治疗后的hs-CR P、IL-6、IL-8和TN F-α的水平分别为(2.06±1.17)mg/L、(8.03±2.24)pg/m L、(16.21±2.16)pg/m L和(18.25±4.93)pg/m L,CD4^+和CD4^+/CD8^+的水平分别为(30.62±8.59)%和1.53±0.74。两组数据比较后,差异具有统计学意义(P<0.05)。结论HA330血液灌洗治疗急性重症胰腺炎可降低炎症因子水平、提升免疫细胞亚群水平,有助于患者机体炎症的缓解和免疫功能的改善。
Objective To observe the clinical effect of HA330 hemoperfusion on patients with severe acute pancreatitis.Me thods 90 patients with severe acute pancreatitis from April 25,2015 to April 24,2017 admitted in a hospital were divided into two groups according to different treatment methods.47 cases given conventional western medicine were in the routine group while 43 cases treated with both conventional western medicine and hemoperfusion were in the research group.The level of inflammatory factors and immune function were observed in the two groups after treatment.Re s ults After treatment,the levels of hs-CRP,IL-6,IL-8 and TNF-alpha of the research group were（0.69±0.44）mg/L,（4.57±1.16）pg/m L,（10.02±1.23）pg/m L and（7.56±2.08）pg/m L respectively and the levels of CD4~＋and CD4~＋/CD8~＋wer（42.54±8.75）%and（2.10±0.78）respectively.In the routine group,after treatment the levels of hs-CRP,IL-6,IL-8 and TNF-alpha wer（2.06±1.17）mg/L,（8.03±2.24）pg/m L,（16.21±2.16）pg/m L and（18.25±4.93）pg/m L respectively and the levels of CD4~＋and CD4~＋/CD8~＋were（30.62＋8.59）%and（1.53±0.74）respectively.The difference between the two groups was statistically significant（P〈0.05）.Conclus ion HA330 hemoperfusion treatment for severe acute pancreatitis can reduce the level of inflammatory factors and enhance the level of immune cell subsets,contributing to the alleviation of inflammation and immune function in patients.
出处
《中国疗养医学》
2017年第12期1275-1276,共2页
Chinese Journal of Convalescent Medicine
关键词
急性重症胰腺炎
血流灌洗
临床效果
Severe acute pancreatitis
Hemoperfusion
Clinical effect
