摘要
目的 评价自拟当归四逆汤联合甲钴胺治疗糖尿病周围神经病变的疗效.方法 将符合入选标准的104例糖尿病周围神经病变患者按随机数字表法分为2组,每组52例.对照组口服甲钴胺,研究组在对照组基础上口服自拟当归四逆汤.2组均治疗4周.采用肌电检测仪测定运动神经传导速度、感觉神经传导速度;采用血液流变检测仪检测全血黏度、血浆黏度和红细胞压积;采用ELISA法检测血清糖基化终末产物（advanced glycosylation end products,AGEs）,评价临床疗效.结果 研究组总有效率为96.2%（50/52）、对照组为82.7%（43/52）,2组比较差异有统计学意义（χ2=4.981,P=0.026）.治疗后,研究组运动神经传导速度[（49.1±4.5）m/s比（42.8±4.3）m/s,t=2.732]、感觉神经传导速度[（40.1±3.7）m/s比（36.5±3.9）m/s,t=2.723]高于对照组（P〈0.05）;全血黏度[（3.72±0.58）mPa？s比（4.55±0.47）mPa？s,t=2.704]、血浆黏度[（1.03±0.12）mPa？s比（1.78±0.09）mPa？s,t=-2.682]、红细胞压积[（31.23±3.19）%比（37.33±4.12）%,t=-2.737]、AEGs[（58.44±4.87）ng/L比（68.03±4.98）ng/L,t=-2.856]低于对照组（P〈0.05）.治疗期间,研究组不良反应发生率为5.8%（3/52）、对照组为3.9%（2/52）,2组比较差异无统计学意义（χ2=0.210,P=0.647）.结论 自拟当归四逆汤联合甲钴胺可改善糖尿病周围神经病变患者外周神经传导速度及血液流变学指标,降低AEGs,提高临床疗效.
Objective To investigate the clinical effect of modified Danggui-Sini decoction combined with Mecobalamin on diabetic peripheral neuropathy. Methods A total of 104 patients with diabetic peripheral neuropathy from January 2015 -2016 year in December in our hospital patients were randomly divided into study group and control group, each of 52 patients. The control group was given Mecobalamin 0.5 mg/times. The study group was given modified Danggui-Sini decoction plus the intervention of the observation group. Four weeks were a course of treatment. The clinical effect rates, the incidence of adverse events, change of common peroneal nerve conduction velocity, hemorheological indexes and advanced glycation end products （AGEs） were compared between the two groups before and after treatment. Results The total effective rate of the study group was 96.2%, which was significantly higher than 82.7% of the control group （χ2=4.981, P〈0.05）. During treatment, the incidence of adverse events was 5.8% in the study group, and the incidence of adverse events in the control group was 3.9%. There was no significant difference in the incidence of adverse reactions between two groups（P〈0.05）.After treatment,the motor nerve conduction velocity（49.1 ± 4.5 m/s vs.42.8 ± 4.3 m/s） and sensory nerve conduction velocity （40.1 ± 3.7 m/s vs. 36.5 ± 3.9 m/s） in the study group were significantly higher than those in the control group （t=2.732, 2.723, P〈0.05）. The whole blood viscosity [（3.72 ± 0.58）mPa？s vs.（4.55 ± 0.47）mPa？s],plasma viscosity[（1.03 ± 0.12）mPa？s vs.（1.78 ± 0.09）mPa？s],erythrocyte blood pressure（31.23% ± 3.19% vs.37.33% ± 4.12%）,AGEs（58.44 ± 4.87 ng/L vs.68.03 ± 4.98 ng/L）in the observation group were significantly lower than those in the control group （t=2.704, -2.682, -2.737, -2.856, P〈0.05）. Conclusions The modified Danggui-Sini decoction combined with Mecobalamin on diabetic peripheral neuropathy can improve peripheral nerve conduction velocit
出处
《国际中医中药杂志》
2017年第11期981-984,共4页
International Journal of Traditional Chinese Medicine
关键词
糖尿病神经病变
当归四逆汤
甲钴胺
临床研究
Diabetic neuropathies
Dang Gui Si Ni Tang
Mecobalamin
Clinical study
