摘要
肾小球疾病是我国慢性肾脏病以及终末期肾衰竭的重要病因,免疫炎症反应是该类疾病发病机制中的核心环节。本创新研究群体的攻关方向是肾小球肾炎的免疫炎症发病机制,特别是最严重的新月体肾炎,包括抗GBM病、ANCA相关小血管炎、狼疮肾炎和IgA肾病。在国家自然科学基金的支持下,团队在自身抗体的抗原表位研究、补体异常活化介导肾脏损伤和在IgA肾病中IgA1分子的异常糖基化方面,取得了一系列创新的研究成果。通过这些研究,深入探讨了肾小球肾炎的免疫炎症发病机制和可能病因,为免疫介导的肾小球肾炎的防治提供潜在的生物标志物和治疗靶点。
Glomerulonephritis is the major cause of chronic kidney disease and end-stage renal disease in China.The immune-mediated inflammation plays a key role in the pathogenesis of glomerulonephritis.Our Innovation Research Group focuses on the immunity and inflammatory pathogenesis of glomerulonephritis,especially in the most severe crescentic glomerulonephritis,including anti-GBM disease,ANCA associated vasculitis,lupus nephritis and IgA nephropathy.Under the support of science funding,we achieved a series of novel findings on the fine epitope（s）of autoimmune T/B cells,complement activation-mediated kidney damage,and aberrant glycosylated IgA1 molecules in IgA nephropathy.Based on these investigations,we have partially elucidated autoimmune and inflammation pathogenesis of glomerulonephritis and revealed potential biomarkers and therapeutic targets for prevention and treatment of immune-mediated glomerulonephritis.
出处
《中国科学基金》
CSSCI
CSCD
北大核心
2017年第6期586-593,共8页
Bulletin of National Natural Science Foundation of China
基金
国家自然科学基金创新研究群体"肾小球免疫炎症发病机制的研究"(项目批准号:81021004)
第一次延续资助(项目批准号:81321064)
第二次延续资助(项目批准号:81621092)的支持
