摘要
目的分析山东地区人群中百日咳杆菌感染情况。方法回顾性收集2015年1月~2016年12月在山东省立医院门诊就诊和住院的患者1 989例,用BP-DNA方法进行咽拭子百日咳杆菌核酸检测。用spss21.08软件分析人群中百日咳杆菌感染情况。结果 1 989例咽拭子标本中,百日咳杆菌核酸检测阳性率为23.06%,男性百日咳杆菌核酸检测阳性率30.78%,略低于女性的34.75%,但差异无统计学意义(P>0.05);百日咳杆菌核酸检测阳性率以0~1岁阳性率最高,占38.72%,以后随着年龄升高阳性率逐渐降低,30岁以上组最低(占比14%);不同季节之间百日咳杆菌核酸检测阳性率差异有统计学意义(P<0.05)。其中夏季检测阳性率最高(40.35%),明显高于秋季的33.11%(P<0.05),秋季明显高于春季的24.8%(P<0.05),春季略高于冬季的19.56%(P>0.05)。结论山东地区人群百日咳杆菌核酸检测阳性率存在年龄和季节差异,应加强对疑似患者的百日咳杆菌核酸检测。
Objective Analysis ofpertussis infection in Shandong area. Methods From January 2015 to December 2016 in Shangdong Provincial Hospital affiliated to Shandong University, BP-DNA analysis was used to detect Bordetella pertussis nucleic acid in 1989 patients. SPSS21.0 software was used to retrospectively analyse Bordetella pertussis infection in population. Results In 1989 throat swab specimens, the positive rate of nucleic acid detection of Bordetella pertussis was 23.06%, the positive rate ofpertussis nucleic acid is 30.78% in male, slightly lower than the 34.75% of women, but there was not statistically significant difference between two groups （P〉0.05） ; the positive rate of nucleic acid of Bordetella pertussis in the age group of 0-1 year old is the highest, accounting for 38.72%, the positive rate decreased gradually with the age increasing, and the positive rate is the lowest in above 30 years old group with 14%; there was significant difference between seasons of Bordetella pertussis nucleic acid detection positive rate （P〈0.05） . Among them, the highest positive rate was 40.35% in summer, which was significantly higher than that in autumn with 33.11% （P〈0.05） , the positive rate in autumn was significantly higher than that in spring with 24.8% （P〈0.05） , and it was slightly higher in spring than in winter with 19.56% （P〉0.05） . Conclusions There was no significant difference in the positive rate of detection of Bordetellapertussis among population in Shandong area, but there were differences in age and season. We should strengthen the detection of Bordetella pertussis nucleic acid in suspected patients.
出处
《临床输血与检验》
CAS
2017年第6期589-591,共3页
Journal of Clinical Transfusion and Laboratory Medicine
基金
山东省自然科学基金资助项目(No.ZR2016HM52
ZR2015PH016)
山东省临床重点专科建设项目(No.鲁卫医字[2013]26号)
山东省医药卫生重点实验室(No.鲁卫科教国合字[2013]49号)资助
关键词
百日咳杆菌
核酸
山东
Bordetella pertussis Nucleic acid Shandong
