摘要
Rab蛋白属于小G蛋白,是Ras超家族中的成员,目前已发现70余种。它们特异性地定位于亚细胞器中并且对胞内蛋白质的囊泡转运起着重要作用。快速的单克隆性增殖与血管淋巴结转移是恶性肿瘤难以控制的生物学因素,与肿瘤患者的预后息息相关。目前的研究已发现许多Rab蛋白在癌细胞中表达失调并且影响了癌细胞的增殖,转移能力,降低了患者的生存预后。因此本文就Rab蛋白在肿瘤发生发展中的研究进展做一综述。
Rab protein belongs to the small G protein, is a member of the Ras super family, now has found more than seventy species. They are specifically localized in subcellular organelles and play an important role in vesicle transport of intracellular proteins. Rapid monoclonal proliferation and blood vessels, lymph node metastasis are the bio-logical factors of malignant tumors that is difficult to control and closely related to the prognosis of cancer patients. The current study has found that many Rab proteins have disorder expression in tumor cell and affect the proliferation and metastasis ability of cancer cells, reducing the survival prognosis of patients. In this paper, the research progress of Rab protein in cancer were reviewed.
出处
《海南医学》
CAS
2017年第20期3368-3371,共4页
Hainan Medical Journal
关键词
RAB蛋白
肿瘤
增殖
转移
预后
Rab GTPases
Tumor
Proliferation
Migration
Prognosis
