摘要
目的:研究胰十二指肠切除术对胰头癌伴壶腹周围癌患者疗效及远期生存率的影响。方法:研究对象选取某院2012年3月~2014年3月间收治的胰头癌伴壶腹周围癌患者108例,使用随机数字表法分为研究组和对照组,每组各54例。研究组患者接受胰十二指肠切除术治疗,对照组患者接受姑息性手术治疗,比较两组患者的术中一般情况(手术时间、出血量)、住院时间及术后并发症发生率,术后随访3年,比较两组患者术后1年复发率以及肿瘤根除率,同时比较两组术后1年、2年及3年生存率。结果:研究组的手术时间和术中出血量均明显高于对照组(P<0.01),两组的住院时间比较无明显差异(P>0.05);研究组的术后总并发症发生率明显高于对照组;术后随访显示,研究组术后2年和3年的生存率明显高于对照组(P<0.05),研究组术后1年的复发率明显低于对照组,研究组的肿瘤根除率明显高于对照组。结论:对于胰头癌伴壶腹周围癌患者采用胰十二指肠切除术,虽延长了手术时间,提高术中出血量及并发症发生风险,但肿瘤根治效果更好,减少术后复发可能,可明显提高远期生存率,有一定临床价值。
Objective： To Study the effect of the efficacy and long-term survival rate of pancreaticoduode- nectomy for pancreatic cancer with periampullary carcinoma. Methods： 108 patients with Pancreatic head cancer with periampullary cancer from March 2012 to March 2017 in a hospital were selected and divided into study group and control group, each group of 54 cases. The patients in the study group were treated with pancreaticoduodenectomy and the control group received palliative surgery. General surgery （operation time, bleeding volume）, length of stay and postoperative complications of two groups were compared. The patients were followed up for 3 years, comparing two groups＂ recurrence rate and tumor eradication rate after 1 year of the oper0tion, and compared two groups＂ survival rate after operation 1 year,2years and 3 years. Results： The operative time and intraoperative blood loss were significantly higher in the study group than in the control group （P〈0.01）. There was no significant difference in the hospitalization time between the two groups （P 〉0.05）.The incidence of postoperative complications was significantly higher in the study group than in the control group; Postoperative follow-up showed that ＇the survival rate of the study group was significantly higher than that of the control group after 2 and 3 years of the operation （P〈0.05）.The recurrence rate of the study group was significantly lower than that of the control group after 1 year of operation. The tumor eradication rate of the study group was significantly higher than that of the control group. Conclusion： Al- though pancreaticoduodenectomy increases the operation time, improves intraoperative blood loss and complications risk, the effect of tumor radical is better. It reduce the possibility of recurrence and can significantly improve long-term survival, with certain clinical value.
出处
《数理医药学杂志》
2017年第12期1742-1745,共4页
Journal of Mathematical Medicine
关键词
胰十二指肠切除术
胰头癌伴壶腹周围癌
近远期疗效
安全性
姑息性手术
pancreaticoduodenectomy
pancreatic cancer with periampullary carcinoma
near-long-term efficacy
safety
palliative surgery
