摘要
1例49岁女性乳腺癌患者接受吉西他滨（1.6 g）联合紫杉醇（120 mg）静脉滴注化疗（第1、8、15天,21 d为1个周期）.查血常规示WBC 0.9 ×109/L,PLT 65 ×109/L,中性粒细胞计数0.3×109/L.化疗方案改为只在第1、8天给药,第15天化疗取消.第2周期第3周（开始此方案治疗后35 d）患者出现咳嗽咳痰,X线胸片示双侧少量胸腔积液,双肺间质病变.考虑为化疗药物致间质性肺炎,予吸氧、祛痰、抗炎等治疗,13 d后患者咳嗽咳痰逐渐好转.因患者化疗后出现粒细胞缺乏,暂停化疗10 d并调整紫杉醇剂量为90 mg.后续随访,患者病情进展,但未再出现间质性肺炎.
A 49-year-old female patient with breast cancer received IV infusion of gemcitabine（1.6 g） and paclitaxel（120 mg）at the day 1,8,and 15（the treatment course was 21 d）. The routine blood test showed WBC 0.9×109/L,PLT 65×109/L,and neutrophil count 0.3×109/L. The chemotherapy regimen was changed to be given at day 1 and 8 of the treatment cycle and the treatment at day 15 was cancelled. At the 3rd week of the 2nd treatment cycle（the 35th day from treatment start）,the patient developed cough and expectoration. Chest X-ray showed a small amount of bilateral pleural effusion and bilateral lung interstitial disease. It was considered that the chemotherapeutic drugs induced the interstitial pneumonia. Treatments with oxygen inhalation,eliminating phlegm and anti-inflammation were given and 13 days later, her cough and expectoration were improved. Because of granulocytic deficiency induced by chemotherapeutic drugs,the chemotherapy was suspended for 10 days and the dose of paclitaxel was changed to 90 mg. At later follow-up,the patient′s condition aggravated,but interstitial pneumonia did not recur.
出处
《药物不良反应杂志》
CSCD
2017年第5期380-381,共2页
Adverse Drug Reactions Journal
关键词
紫杉酚
肺疾病
间质性
吉西他滨
Paclitaxel
Lung diseases, interstitial
Gemcitabine
