摘要
目的揭示血浆和肽素浓度对重型颅脑损伤患者住院期间死亡的预测价值。方法 ELISA法测定98例重型颅脑损伤患者和98健康体检者血浆和肽素、S100B蛋白、神经元特异性烯醇化酶、髓鞘碱性蛋白和胶质纤维酸性蛋白浓度,ROC曲线分析血浆和肽素浓度对患者住院期间死亡的预测价值,并与入院时格拉斯哥昏迷评分及其他生化指标的预测价值作比较。结果 t检验显示,重型颅脑损伤患者入院时血浆和肽素、S100B蛋白、神经元特异性烯醇化酶、髓鞘碱性蛋白和胶质纤维酸性蛋白浓度均较健康体检者显著升高(均P<0.01);住院期间死亡患者血浆中各生化指标浓度均较生存患者显著升高(均P<0.01)。Pearson相关分析显示,血浆和肽素浓度与血浆中各生化指标浓度均呈显著正相关(均P<0.01),与入院时格拉斯哥昏迷评分呈显著负相关(P<0.01)。ROC曲线分析显示,血浆和肽素浓度可显著预测重型颅脑损伤患者住院期间死亡的发生(P<0.01),与入院时格拉斯哥昏迷评分及其他生化指标的预测价值作比较,差异均无统计学意义(P>0.05)。结论重型颅脑损伤患者血浆和肽素浓度显著升高,该指标测定可显著预测重型颅脑损伤患者住院期间死亡的发生。
Objective To explore the predictive value of plasma copeptin concentration for in-hospital death of patients with severe traumatic brain injury. Methods Plasma copeptin, neuron specific enolase, S100B, myelin basic protein and glial fibrillary acidic protein concentrations of 98 patients with severe traumatic brain injury and 98 healthy controls were measured using ELISA. ROC curve was used to analyze predictive value of plasma copeptin concentration for in-hospital death of patients and compare its predictive value with those of Glasgow Coma Scale score on admission and other biochemical markers. Results t test showed, plasma copeptin, neuron specific enolase, S100B, myelin basic protein and glial fibrillary acidic protein concentrations were obviously higher in patients with severe traumatic brain injury than in healthy controls（all P〈0.01）, and in nonsurvivors than survivors（all P〈0.01）. Using Pearson correlation coefficient, plasma copeptin concentration was positively associated with plasma concen-trations of other biochemical markers（all P〈0.01） and negatively with admission Glasgow Coma Scale score（P〈0.01）. Receiver operating characteristic curve analysis demonstrated that plasma copeptin concentration statistically significantly predicted in-hospital death of patients with severe traumatic brain injury（P〈0.01）. When its predictive value was compared with those of admission Glasgow Coma Scale score and plasma concentrations of other biochemical markers, there were no statistically significant differences（all P〉0.05）. Conclusion Plasma copeptin concentration increases obviously in patients with severe traumatic brain injury and the determination of this marker can predict markedly in-hospital death of patients with severe traumatic brain injury.
出处
《浙江创伤外科》
2017年第5期822-824,共3页
Zhejiang Journal of Traumatic Surgery
关键词
重型颅脑损伤
和肽素预后
死亡
Severe traumatic brain injury
Copeptin
Prognosis
Death
