摘要
目的观察肺炎支原体肺炎(MPP)患儿免疫功能的变化。方法 114例肺炎支原体肺炎(MPP)患儿作为实验组,于病程第7~10天检测MPIgM抗体为阳性,并采集外周血标本。同期保健门诊体检的50例健康儿童作为对照组,采集外周血标本。分别检测外周血标本中T细胞亚群(CD_3、CD_4、CD_8、CD_4/CD_8、NK)以及体液免疫(IgG、IgA、IgM、C3、C4)的水平。结果实验组患儿血清中CD_3、CD_4、CD_4/CD_8比值、NK值均显著低于正常对照组(P<0.05),IgA、C3和C4均显著低于正常对照组(P<0.05),而IgG和IgM值无显著差异(P>0.05)。结论肺炎支原体(MP)感染可引起免疫功能紊乱,抑制细胞免疫及体液免疫。
ObjectiveTo observe the change of immunologic function in children with mycoplasma pneumoniae pneumonia （MMP）. MethodsTotally 114 children diagnosed with MPP were selected as experimental group, and MPIgM were positively detected in the course of 7 to 10 days, and the blood samples were collected. At the same time, 50 healthy children in health clinic were selected as control group, and peripheral blood samples were collected. The levels of T cell subsets （CD3, CD4, CD8, CD4/CD8, NK） and humoral immunity （IgG, IgA, IgM, C3, C4） in peripheral blood samples were detected respectively. ResultsThe serum CD3, CD4, CD4/CD8 ratio and NK value in the experimental group were significantly lower than those in the control group （P〈0.05）, and IgA, C3 and C4 were significantly lower than those in the control group （P〈0.05）, but there was no significant difference in IgG and IgM values （P〉0.05）. ConclusionMycoplasma pneumoniae （MP） infection can cause immune dysfunction, inhibit cellular immunity and humoral immunity.
出处
《实用临床医药杂志》
CAS
2017年第21期39-41,共3页
Journal of Clinical Medicine in Practice
关键词
肺炎支原体肺炎
T细胞亚群
体液免疫
mycoplasma pneumoniae pneumonia
T lymphocyte subsets
humoral immunity
