摘要
目的探讨红霉素序贯疗法对支原体肺炎患儿免疫球蛋白、细胞因子变化以及对患儿预后的影响。方法选择2014年2—9月就诊于本院儿科的支原体肺炎患儿118例,采用随机数字表法将患儿分为观察组与对照组各59例。观察组采用红霉素序贯疗法,对照组采用常规红霉素单纯静脉滴注疗法,比较两组患儿的免疫球蛋白、细胞因子水平及患儿预后(有效率及不良反应发生率)。结果治疗前,两组IgA、IgM、IgG水平比较,差异无统计学意义(P>0.05);治疗后,观察组的IgA、IgM、IgG水平均较对照组升高,差异有统计学意义(P<0.05)。治疗前,两组IL-6、IL-8比较,差异均无统计学意义(P>0.05);治疗后,观察组的IL-6、IL-8水平低于对照组,差异有统计学意义(P<0.05)。观察组患儿的有效率高于对照组,差异有统计学意义(P<0.05)。观察组仅1例发生皮疹,对照组发生胃肠道反应2例、皮疹3例、药物热2例,观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论采用红霉素序贯疗法有助于提高支原体肺炎患儿的免疫球蛋白水平、改善细胞因子水平,在提高患儿治疗有效率的同时,不良反应发生率低,安全性高,值得临床推广。
Objective To investigate the changes of immunoglobulin and cytokines in children with mycoplasma pneumonia in children after erythromycin sequential therapy. Methods 118 cases of children with mycoplasma pneumonia in our hospital as the main object of observation,the children were randomly divided into observation group and control group,each group of 59 cases,The observation group used erythromycin sequential therapy,control group with routine intravenous injection of erythromycin therapy,compared two groups of children with immunoglobulin,cytokines and prognosis( with efficiency and adverse reaction rate). Results The observation group and control group before treatment, no significant difference( P >0. 05); the observation group and the control group with immunoglobulin IgA,IgM and IgG levels were significantly difference after treatment( P < 0. 05). The treatment group and control group before cytokines( IL-6,IL-8) showed no significant difference( P > 0. 05); observation group and the control group of cytokines( IL-6,IL-8) was significantly differenc after treatment( P < 0. 05). In the observation group, only 1 cases had skin rash, while the control group had gastrointestinal reaction in 2 cases, skin rash in 3 cases, and drug fever in the observation group, the incidence of adverse reactions was significantly lower than that of the control group( P < 0. 05). Conclusion the erythromycin sequential method is helpful to improve the quantity and immunoglobulin in children with mycoplasma pneumonia relieve cytokine levels reduced degree in improving the treatment efficiency of children at the same time,reduce the incidence of adverse reaction,high safety,worthy of promotion.
出处
《中国全科医学》
CAS
北大核心
2017年第A01期118-120,共3页
Chinese General Practice
关键词
红霉素
儿童
支原体肺炎
免疫球蛋白
细胞因子
Erythromycin sequential
Children
Mycoplasma pneumonia
Immunoglobulin
Cytokines
