摘要
目的探讨糖类抗原125(CA125)水平与特发性炎性肌病(IIM)患者肺动脉压的关系。方法选取2008年9月—2014年8月成都市第三人民医院及海南省人民医院收治的IIM患者54例,根据CA125水平分为异常组15例与正常组39例。比较两组患者临床特征和实验室检查指标,CA125水平与IIM患者肺动脉压的相关性分析采用Pearson相关性分析,异常组患者肺动脉压的相关因素分析采用多元线性回归分析。结果两组患者性别、年龄、病程、疾病类型、吞咽困难发生率、肌痛发生率、关节痛发生率、皮疹发生率、雷诺现象发生率、免疫抑制剂及糖皮质激素使用率、收缩压、舒张压、心率、红细胞计数、白细胞计数、血小板计数、总胆红素水平、直接胆红素水平、间接胆红素水平、血糖、三酰甘油水平、总胆固醇水平、低密度脂蛋白胆固醇水平、高密度脂蛋白胆固醇水平、肌酐水平比较,差异无统计学意义(P>0.05);两组患者肺动脉压、血尿酸水平比较,差异有统计学意义(P<0.05)。Pearson相关性分析结果显示,CA125水平与IIM患者肺动脉压呈正相关(r=0.341,P<0.05)。多元线性回归分析结果显示,CA125水平是异常组患者肺动脉压的相关因素[b=0.039,95%CI(0.007,0.072),P<0.05]。结论CA125水平与IIM患者肺动脉压有关。
Objective To investigate the relationship between CA125 level and pulmonary arterial pressure in patients with idiopathic inflammatory myopathies. Methods A total of 54 patients with idiopathic inflammatory myopathies were selected in the Third People＇s Hospital of Chengdu and Hainan Provincial People＇ s Hospital from September 2008 to August 2014,and they were divided into A group（ with abnormal CA125 level, n = 15） and B group（ with normal CA125 level, n = 39）according to the CA125 level. Clinical features and laboratory examination results were compared between the two groups,Pearson correlation analysis was used to analyze the correlation between CA125 level and pulmonary arterial pressure in patients with idiopathic inflammatory myopathies,meanwhile multivariate linear regression analysis was used to analyze the related factors of pulmonary arterial pressure in idiopathic inflammatory myopathies patients with abnormal CA125 level. Results No statistically significant differences of gender,age,disease course,types of illness,incidence of dysphagia,myalgia,arthralgia,rash or Raynaud＇s phenomenon,utilization rate of immunosuppressant or glucocorticoid,SBP,DBP,heart rate,RBC,WBC,PLT,TBi L,DBi L,IBi L,FPG,TG,TC,LDL-C,HDL-C or Cr was found between the two groups（ P〈0. 05）,while there were statistically significant differences of pulmonary arterial pressure and BUA between the two groups（ P〈0. 05）. Pearson correlation analysis results showed that,CA125 level was positively correlated with the pulmonary arterial pressure in patients with idiopathic inflammatory myopathies（ r = 0. 341,P〈0. 05）. Multivariate linear regression analysis results that,CA125 level was the related factor e in idiopathic inflammatory myopathies patients with abnormal CA125 level [b = 0. 039,95% CI（ 0. 007,0. 072）,P〈0. 05]. Conclusion CA125 level was significantly correlated with the pulmonary arterial pressure in patients with idiopathic inflammatory myopathies.
出处
《实用心脑肺血管病杂志》
2017年第10期64-67,共4页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
国家自然科学基金青年科学基金项目(81300243)
四川省医学科研青年创新课题(Q14013)
四川省卫计委普及应用项目(16PJ042)
关键词
肌炎
肺动脉压
糖类抗原125
Myositis
Pulmonary arterial pressure
Carbohydrate antigen 125
