摘要
目的探讨调强适形放疗(IMRT)联合顺铂化疗治疗鼻咽癌的临床疗效。方法选取2013年10月至2015年12月间广东省肇庆市第二人民医院收治的80例鼻咽癌患者,根据治疗方法不同分为IMRT组41例和联合组39例。IMRT组采用IMRT治疗,联合组采用IMRT联合顺铂化疗治疗,比较两组患者放疗结束后1年和3年的生存率和远期疗效,评价两组患者治疗不良反应。结果联合组患者3年无瘤生存率和3年无进展生存率均高于IMRT组患者,差异均有统计学意义(均P<0.05)。两组患者1年无瘤生存率和1年无进展生存率,及1年和3年的无局部复发生存率和无远处转移生存率比较,差异均无统计学意义(均P>0.05)。联合组患者2年和3年生存率均高于IMRT组患者,差异均有统计学意义(均P<0.05)。联合组患者颈部淋巴结肿瘤体积(GTVnd)缩小比例高于IMRT组,皮下纤维化率低于IMRT组,差异均有统计学意义(均P<0.05)。两组患者口干率、听力受损率和肝功能受损率比较,差异均无统计学意义(均P>0.05)。结论调强适形放疗联合顺铂化疗治疗鼻咽癌远期疗效较好,能有效降低不良反应,提高术后生存率。
Objective To investigate the clinic efficacy of intensity-modulated radiotherapy（ IMRT） combined with cisplatin chemotherapy in treating nasopharyngeal cancer（ NPC）. Methods A total of 80 NPC patients treated at our Second People＇s Hospital of Zhaoqin from October 2013 to December 2015 were selected and were divided into IMRT group（ 41 patients） and combination group（ 39 patients）. IMRT group was treated with IMRT and the combination group was treated with IMRT combined with cisplatin chemotherapy. The 1-and 3-year survival rate and long-term efficacy were recorded. Adverse reactions to radiotherapy and chemotherapy were evaluated. Results The 3-year disease free survival and 3-year progression-free survival were higher in the combination group than IMRT group（ all P〈0. 05）. There was no statistically significant difference in 1-year DFS,1-year PFS and 1-year and 3-year local recurrence-free survival and distant metastasis-free survival between the two groups（ P〈0. 05）. The 2-and 3-year survival rates were higher in the combination group than IMRT group（ P〈0. 05）. The proportion of reduction in the neck lymph nodes（ GTVnd） was higher in the combination group than IMRT group（ P〈0. 05）. The subcutaneous fibrosis rate was lower in the combination group than IMRT group（ P〈0. 05）. No statistically significant difference was noted in the rate of dry mouth,hearing impaired and liver dysfunction between the two groups（ all P〈0. 05）. Conclusion IMRT combined with cisplatin chemotherapy was efficacy in treating NPC,which can improve long-term treatment efficacy,lower the adverse reactions and improve postoperative survival rate in NPC patients.
出处
《中国肿瘤临床与康复》
2017年第11期1369-1372,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
基金
肇庆市科技创新计划项目(2014E217)
关键词
调强适形放疗
顺铂
鼻咽肿瘤
Intensity-modulated radiation therapy
Cisplatin
Nasopharyngeal neoplasms
