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双水平正压通气治疗心脏术后严重低氧血症的临床效果

Clinical effect of Bi-level positive airway pressure ventilation in the treatment of severe hypoxemia after cardiac surgery
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摘要 目的:观察双水平正压通气(BiLevel)治疗心脏术后严重低氧血症的临床效果。方法:2016年6月至2017年3月,我们应用PB840呼吸机(美国泰科)的BiLevel通气模式,对32例心脏术后严重低氧血症经其他通气模式治疗无效的患者进行呼吸治疗,其中男性19例,女性13例,年龄33~72岁(平均53±12岁),非体外冠状动脉旁路移植术17例,胸主动脉手术3例,瓣膜手术12例。高压相(PEEPH)20~25cm H_2O(1cm H_2O=0.098k Pa),低压相(PEEPL)10~15cm H_2O,呼吸频率12~16次/min,TH∶TL为1∶2,压力支持(PS)5~10 cm H_2O,流量触发3L/min,压力上升百分比(FAP)50%,有效患者呼气努力(Esens)30%,起始吸入氧浓度60%~80%,根据病情调整至30%~50%。观察应用Bi Level通气模式前(T1)以及之后2h(T2)、6h(T3)、12h(T4)的氧合指数(OI)、二氧化碳分压(PaCO_2)、心率(HR)、平均动脉压(MAP)等指标的变化。严重低氧血症定义为氧合指数≤200。结果:本组患者应用BiLevel通气模式治疗2 h后患者氧合指数明显改善(162±16)vs.(174±14)mm Hg,12h后持续改善(174±14)vs.(261±33)mm Hg,二氧化碳分压(27±2)vs.(37±2)mm Hg、呼吸频率(32±3)vs.(22±3)次/min、心率(104±8)vs.(84±4)次/min、平均动脉压(94±5)vs.(89±3)mm Hg等指标均明显好转。治疗过程中患者与呼吸机协调性良好,未发生循环不稳定及气胸等不良事件。结论:BiLevel通气模式是治疗心脏术后严重低氧血症的有效方法,有助于患者氧合改善,应调整适当的参数水平以达到最佳同步性及治疗效果并减少并发症。 Objective: To observe the clinical effect of Bilevel positive airway pressure ventilation in the treatment of severe hypoxemia after cardiac surgery. Methods: From June 2016 to March 2017, we used BiLevel positive airway pressure ventilation mode of PB840 ventilator (Tyco of USA) on 32 cases of severe hypoxemia patients after cardiac surgery who are refractory to other modes of ventilation of respiratory therapy, including 19 cases of male, 13 cases of female, aged from 33 to 72 years old (average 53 ±12 years), 17 cases of off-pump coronary artery bypass grafting, 3 cases of thoracic aortic surgery, 12 cases of valvular surgery. Ventilator settings : High pressure phase (PEEPH) 20 -25cmH2O, low voltage (PEEPL) of 10-15cmH2O, respiratory frequency 12 -16 times/min, TH: TL = 1: 2, pressure support (PS) from 5 to 10 cmH2O, the flow trigger 3L/min, percentage of pressure rise ( FAP% ) is 50%, effective expiratory effort (Esens) is 30%, from the beginning, the inhaled oxygen concentration from 60-80% , adjustment to 30-50% according to the patient' s condition. To observe the change of oxygenation index (OI), partial pressure of carbon dioxide (PaCO2 ) , heart rate (HR), mean arterial pressure (MAP) and other indicators before the application of Bi- Level ventilation mode (T1) and after the usage of Bilevel for 2h(I2), 6h ( T3 ), 12h (T4). Severe hypoxemia is defined as the oxygenation index is less than or equal to 200. Results: This group of patients with treatment of BiLevel ventilation for 2 hours, the oxygenation index (OI) were significantly improved ( 162 ±16 ) vs. (174 ± 14), and improved continuously after 12 hours of treatment( 174 ± 14)vs. (261 ± 33) mmHg. The indicators such as carbon dioxide partial pressure (27 ± 2) vs. (37 ± 2) mmHg, respiratory frequency (32 ± 3 ) vs. (22 ± 3 ) times/min, heart rate ( 104 ± 8) vs. ( 84 ± 4) times/min and mean arterial pressure (94 ± 5 )
出处 《心肺血管病杂志》 2017年第9期732-734,共3页 Journal of Cardiovascular and Pulmonary Diseases
关键词 双水平正压通气 心脏外科手术 低氧血症 BiLevel positive pressure ventilation Cardiac surgery Hypoxemia
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