摘要
转录激活因子3(activating transcription factor,ATF3)属于转录因子ATF/CREB家族的成员,是一种适应反应基因,参与多种细胞活动的调控以适应细胞内外环境的变化。近年来的研究表明,ATF3作为抑癌或致癌基因在消化道系统肿瘤的发生及演变过程中发挥重要的作用。现就ATF3在消化系统肿瘤方面的研究进展作一概述。
Activating transcription factor 3 （ATF3） is a member of the ATF/CREB transcription factor family and a kind of adaptive reaction gene. It involved in a variety of regulating cell activity to adjust to changes in the extra- and intra-cellular environment. It has been identified as either an oncogene or a tumor suppressor and plays an important role in the occurrence and progression of the digestive malignant tumor. The research advances of ATF3 in digestive malignant cancer were reviewed.
出处
《胃肠病学和肝病学杂志》
CAS
2017年第11期1305-1308,共4页
Chinese Journal of Gastroenterology and Hepatology
基金
河南省科技厅基础与前沿项目(122300410401)
关键词
转录激活因子3
消化系统肿瘤
Activating transcription factor 3
Digestive malignant tumor
