摘要
目的比较不同剂量雌激素预防Ⅱ度宫腔粘连术后复发效果。方法选取Ⅱ度宫腔粘连患者120例,宫腔粘连分离术后宫腔内留置注水Foley导尿管球囊7天及戊酸雌二醇及地屈孕酮人工周期治疗3个月,根据戊酸雌二醇剂量不同分为2 mg组(40例)、4 mg组(40例)、9 mg组(40例)。观察3组患者月经改善情况及宫腔形态恢复情况。结果 2 mg组月经改善30例(有效率75%),4 mg组38例(有效率95%),9 mg组40例(有效率100%),差异有统计学意义(P>0.05)。2 mg组27例患者宫腔恢复正常或基本正常(有效率67.5%),4 mg组35例(有效率87.5%),9 mg组39例(有效率97.5%),差异有统计学意义(P<0.05)。2 mg组发生不良反应1例(发生率2.5%),4 mg组4例(发生率10%),9 mg组12例(发生率30%),差异有统计学意义(P<0.05)。4 mg组、9 mg组在月经恢复及宫腔形态恢复上差异均无统计学意义(P>0.05);2 mg组、4 mg组不良反应率比较,差异无统计学意义(P>0.05)。结论Ⅱ度宫腔粘连分离术后采用4 mg戊酸雌二醇治疗即可有效预防宫腔再粘连,改善患者月经,无明显副作用,经济适用,安全有效。
Objective To compare the effect of different doses of estrogen on recurrence of II degree intrauterine adhesions.Methods 120 patients of II degree intrauterine adhesions suffered were given estrogen and progesterone artificial cycle therapy for 3 months after hysteroscopy.All patients divided into 2mg group(40cases),4mg group(40cases),9mg group(40cases).Observe the improvement of menstruation and the recovery of uterine cavity in 3 groups.Results 30 patients menstruation improved in 2mg group (effective power 75%),38 patients in 4mg group (effective power 95%),40 patients in 9mg group (effective power 100%),the difference was statistically signifcant (P〈0.05),no signifcant difference in 4mg group and 9mg group (P〉0.05).27 patients uterine cavities recovered normal in 2mg group (effective power 67.5%),35 patients in 4mg group (effective power 87.5%),39 patients in 9mg group (effective power 95%),the difference was statistically signifcant (P〈0.05),no signifcant difference in 4mg group and 9mg group (P〉0.05).1 patients occur adverse reactions in 2mg group(incidence rate 2.5%),4 patients in 4mg group(incidence rate 10%),12 patients occur adverse reactions in 9mg group(incidence rate 12.5%), the difference was statistically signifcant (P〈0.05),no signifcant difference in 2mg group and 4mg group (P〉0.05).Conclusion 4mg estrogen used in II degree intrauterine adhesions after surgery can prevent adhesion recurrence, improve the menstrual,no obvious side effects,affordable,safe and effective.
出处
《实用妇科内分泌电子杂志》
2017年第17期52-54,共3页
Electronic Journal of Practical Gynecological Endocrinology
关键词
宫腔粘连
戊酸雌二醇
雌激素
人工周期
intrauterine adhesions
estradiol valerate
estrogen
artifcial cycle