摘要
目的对鼠双微粒体(MDM2)单核苷酸多态性与胶质母细胞瘤易感性的关联进行分析。方法本研究在Pub Med、Google Scholar、中国知网、百度学术等数据库对相关检索词组合进行不限定检索,通过文献筛选,最终确定6篇病例对照研究中的样本为试验对象,对MDM2 SNP309与肿瘤的关联性进行Meta分析。结果 Meta分析的结果表明,MDM2 SNP309杂合和纯合突变型与胶质母细胞瘤的易感性有关联,比值比(OR)=1.23[95%置信区间(CI):1.05~1.44],I^2检验P=0.288;杂合突变型尤为突出,OR=1.35(95%CI:1.05~1.73);按人种的亚组分析可知,高加索人的关联性较强,OR=1.30(95%CI:1.08~1.57),I^2检验P=0.410。结论本研究中的Meta分析提示了MDM2SNP309突变与胶质母细胞瘤发生的密切联系,强调了不同人种中关联程度的不同,突出了高加索人种中杂合型突变在易感性中发挥的作用。
Objective To explore the association of MDM2 single nucleotide polymorphism with the risk of glioblastoma.Methods This study has searched a great number of papers using key terms based on Pub Med,Google Scholar,CNKI,Baidu Scholar before screening samples.To investigate the interaction between MDM2 SNP309 and glioblastoma risk,was performed a Meta-analysis of the risk estimate on case-control studies from six qualified articles.Results The data we reviewed indicated that variant homozygote and heterozygote for MDM2 SNP309 were associated with an increased risk of glioblastoma by 1.23 on odds radio（OR）（95%CI：1.05-1.44）,P=0.288 by I^2 test; was performed variant heterozygote of SNP309 significantly increased the risk of cancer by 1.35 on OR（95%CI：1.05-1.73）.In a stratified analysis by ethnicity,this study certified that a significant increased risk in Caucasian by1.30 on OR（95% CI：1.08-1.57）,P =0.410 by I^2 test.Conclusion The analysis indicate MDM2 SNP309 serves as a susceptibility marker on glioblastoma,which was clarified the different risks in ethnicity,especially in Caucasian with variant heterozygote.
出处
《中华神经创伤外科电子杂志》
2017年第5期284-291,共8页
Chinese Journal Of Neurotraumatic Surgery：Electronic Edition
基金
上海市科学技术委员会科研计划项目(12ZR1423400)
