摘要
目的探讨铝碳酸镁联合多潘立酮治疗胆囊切除后胆汁反流性胃炎的疗效。方法选取90例胆汁反流性胃炎患者,随机分为铝碳酸镁组、多潘立酮组和联合组,每组30例。比较3组患者治疗前、治疗2周及4周时的临床疗效、症状积分改善情况、胆汁变化相关指标及HAMA评分。结果联合组总有效率为93.33%,显著高于铝碳酸镁组的80.00%和多潘立酮组的83.33%(P<0.05)。3组治疗后的症状积分改善情况、胆汁变化相关指标、HAMA评分均较治疗前显著改善(P<0.05),且3组两两比较差异均有统计学意义(P<0.05)。结论铝碳酸镁与多潘立酮均能有效治疗胆汁反流性胃炎患者,但二药联合具有更强的协同治疗效果,能显著改善患者症状积分和胆汁变化指标水平,降低患者的焦虑程度,疗效优于单一用药,值得临床推广应用。
ObjectiveTo explore the effect of hydrotalcite combined with domperidone on treatment of patients with bile reflux gastritis after cholecystectomy. MethodsA total of 90 patients with bile reflux gastritis were selected and randomly divided into hydrotalcite group, domperidone group and combined group, 30 cases in each group. Clinical effect, improvement state of symptoms score, related factors of bile fluid change and HAMA score before treatment and 2 and 4 weeks after treatment were compared among three groups. ResultsTotal effective rate of combined group was 93.33%, which was significantly higher than 80.00% of hydrotalcite group and 83.33% of domperidone group （P〈0.05）. After treatment, improvement state of symptoms score, related factors of bile fluid change and HAMA score significantly improved when compared with those before treatment in three groups （P〈0.05）, and there were also significant differences among three groups （P〈0.05）. ConclusionBoth hydrotalcite and domperidone can effectively treat patients with bile reflux gastritis, but the combination of the two drugs has a strong synergistic therapeutic effect, which can significantly improve the symptoms score and related factors of bile fluid change, reduce the anxiety degree of patients, and curative effect is better than the single drug, so it is worthy of clinical application and popularization.
作者
钱浩
QIAN Hao(Yangzhou Hospital of Traditional Chinese Medicine, Yangzhou, Jiangsu, 22500)
出处
《实用临床医药杂志》
CAS
2017年第19期66-69,共4页
Journal of Clinical Medicine in Practice
