摘要
DNA甲基化作为重要的表观遗传修饰,主要发生在CpG岛,通过DNA甲基化转移酶催化完成。DNA甲基化调控基因表达,在细胞分化、遗传印记和肿瘤的治疗等方面起着重要作用。论文概述了DNA甲基化基本概念,总结了DNA甲基化在生长抑制中的作用机制,包括降低生长相关激素的表达,阻滞细胞周期的进程,诱导细胞凋亡,阻止血管生成及抑制或激活DNA甲基化转移酶的表达和活性,展望了DNA甲基化在揭示人类疾病机制,促生长药物和抗癌药物的研发等方面的发展前景。
As an important epigenetic modification, DNA methylation mainly occurs in the CpG island of genes by DNA methyltransferase.DNA methylation regulates gene expression and plays an important role in cell differentiation, genetic imprinting and treatment of tumor.This paper summarized the basic concepts of DNA methylation, as well as mechanisms of DNA methylation in the growth inhibition,including inhibition of growth related hormonal expression and angiogenesis, blocking cell cycle, inducing apoptosis, inhibition or activation of DNA methyltransferase.It also outlooked prospect of DNA methylation in the mechanism of human diseases and in the research of promoting growth as well as anticancer drugs.
出处
《动物医学进展》
北大核心
2017年第11期98-102,共5页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(31572575)
中央高校基本科研业务费专项基金项目(2662016PY115)
