摘要
目的调查2015年河北省53所医疗机构临床分离的肺炎链球菌对常用抗菌药物的耐药现状,为区域内临床合理用药提供支持。方法按细菌耐药性监测方案要求,收集河北省53所细菌耐药性监测网成员单位临床分离的肺炎链球菌数据,药敏试验参照CLSI 2014标准,用WHONET 5.6分析数据。结果共分离肺炎链球菌2 408株,占革兰阳性菌分离数第3位。分离的肺类链球菌对万古霉素、莫西沙星的敏感率均>95%;而对红霉素、克林霉素、甲氧苄啶-磺胺甲唑的耐药率较高,分别为96.4%、89.3%和67.4%;成人与儿童耐药情况基本一致。结论河北省内53所医院临床分离肺炎链球菌耐药情况总体与全国水平一致,但是仍有对个别抗菌药物耐药率增高。应警惕肺炎链球菌耐药菌株的出现,控制耐药菌的发生。
Objective To investigate the antimicrobial resistance of Streptococcus pneumoniae strains isolated from multiple medical institutions across Hebei Province in 2015. Methods The bacterial data were collected from 53 member hospitals of Hebei Antimicrobial Resistance Investigation Net(HEBARIN) according to the unified surveillance program in Hebei province. WHONET 5.6 was used to review, analyze and summarize the surveillance data. The results were interpreted according to CLSI guideline 2014. Results A total of 2 408 strains of S. pneumoniae were included in this analysis. S. pneumoniae was the third most frequently isolated gram positive bacteria. More than 95% of these S. pneumoniae strains were susceptible to vancomycin and moxifloxacin. However, 96.4%, 89.3% and 67.4% of these strains were resistant to erythromycin, clindamycin, and trimethoprim-sulfamethoxazole, respectively. The antimicrobial susceptibility profile was similar between the strains isolated from adults and those isolates from children. Conclusions The antimicrobial resistance profile of S. pneumoniae isolates in Hebei Province is generally consistent with the nation-wide data, except higher resistance level to a few antimicrobial agents. We should be alert to and control the emergence of resistant S. pneumoniae.
出处
《中国感染与化疗杂志》
CAS
CSCD
北大核心
2017年第6期668-671,共4页
Chinese Journal of Infection and Chemotherapy
关键词
肺炎链球菌
耐药性
监测
Streptococcus pneumoniae
antibiotic resistance
surveillance
