摘要
目的探讨新疆维吾尔族老年男性代谢综合征(metabolic syndrome,MS)与骨密度(bone mineral density,BMD)的相关性。方法采用双能X线吸收测定法检测366例[分为MS组(236例)和非MS组(130例)]新疆维吾尔族老年男性的骨密度,通过全自动生化分析仪检测空腹血糖(fasting blood glucose,FBG)、总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、血钙(Ca)、25羟维生素D[25(OH)D]、血清总睾酮(T)、血红蛋白(Hb),测量血压[血管收缩压(systolic blood pressure,SBP)和血管舒张压(diastolic blood pressure,DBP)],测量身高、体重,计算体质量指数(body mass index,BMI)。结果新疆维吾尔族老年男性MS患者骨质疏松检出率高于非MS组,MS组与非MS组间年龄、BMI、FBG、HDL-C、SBP、DBP组间差异有统计学意义(P<0.05)。无论是否为MS患者,骨质疏松患者Hb、TC、HDL-C均低于非骨质疏松患者(P<0.05)。MS组中骨质疏松患者BMI低于非骨质疏松患者,非MS组中非骨质疏松患者25(OH)D高于骨质疏松患者(P<0.05)。骨密度与HDL-C的水平呈负相关(标化B=-0.538,P=0.003),与BMI呈正相关(标化B=0.054,P=0.002),与Hb呈正相关(标化B=0.022,P=0.000)。结论新疆维吾尔族老年男性代谢综合征患者发生骨质疏松的风险取决于各影响因素间的平衡。
Objective To investigate the relationship between metabolic syndrome（MS） and bone mineral density（BMD） in elder Uyghur men.Methods BMD was measured in 366 elder Uyghur men（236 cases in MS group and 130 cases in non-MS group） with dual energy X-ray absorptiometry.Fasting blood glucose（FBG）,triglyceride（TG）,high-density lipoprotein cholesterol（HDL-C）,blood calcium（Ca）,vitamin D3（vitD3）,total testosterone（T）,and hemoglobin（Hb） were measured with an automatic biochemistry analyzer.Blood pressure（systolic blood pressure,SBP,and diastolic blood pressure,DBP） was measured.Body mass index（BMI） was calculated.Results The detection rate of osteoporosis in MS group was higher than that in non-MS group in elder Uighur males.There were statistical differences in age,BMI,FBG,HDL-C,SBP,and DBP between MS and non-MS group（P〈0.05）.In both groups,the levels of Hb,TC,and HDL-C in patients with osteoporosis were lower than those in non-osteoporosis patients（P〈0.05）.BMI in osteoporosis patients was lower than that in non-osteoporosis patients in MS group.25（OH） D in non-osteoporosis patients was higher than that in osteoporosis patients in non-MS group（P〈0.05）.BMD was negatively correlated with HDL-C（standardized B=-0.538,P=0.003）,but was positively correlated with BMI（standardized B=0.054,P=0.002） and Hb（standardized B=0.022,P=0.000）.Conclusion The risk of osteoporosis in Xinjiang Uygur men with metabolic syndrome depends on the balance between all the factors.
出处
《中国骨质疏松杂志》
CAS
CSCD
北大核心
2017年第11期1472-1475,共4页
Chinese Journal of Osteoporosis
