摘要
目的:探讨非小细胞肺癌(NSCLC)生存素(Survivin)、S期激酶相关蛋白2(Skp2)和X连锁凋亡抑制蛋白(XIAP)mRNA的表达及其临床意义。方法:收集2014年4月到2017年5月期间我院182例NSCLC患者在手术中切除的病理组织作为研究组,另收集每例患者癌变组织旁5cm以外的癌旁组织作为对照组。比较两组的Survivin、Skp2和XIAP mRNA阳性率,并分析Survivin、Skp2和XIAP mRNA表达与临床病理特征的关系。结果:研究组的Survivin、Skp2和XIAP mRNA阳性率显著高于对照组,差异有统计学意义(P<0.05)。Survivin m RNA的阳性表达与年龄、性别、组织类型、分化程度、临床分期、淋巴结转移、吸烟史无关(P>0.05)。Skp2 mRNA的阳性表达与年龄、性别、组织类型、分化程度、淋巴结转移、吸烟史无关(P>0.05),与临床分期相关(P<0.05)。XIAP mRNA的阳性表达与年龄、性别、组织类型、分化程度、吸烟史无关(P>0.05),与临床分期、淋巴结转移相关(P<0.05)。结论:Survivin、Skp2和XIAP m RNA在NSCLC患者的病理组织中呈高表达,Skp2 m RNA的阳性表达与临床分期有关,XIAP mRNA的阳性表达与临床分期、淋巴结转移有关。
Objective： To investigate the expression and clinical significance of survivin（Survivin）, S-phase kinase associated prorein 2（Skp2）and X-linked inhibitor of apoptosis protein （XIAP） mRNA in non-smaU cell lung cancer（NSCLC）. Methods： The pathological tissues of 182 patients with NSCLC, who underwent surgical resection in Third People＇s Hospital of Yurman Province during April 2014 to May 2017, were collected as study group; in addition, the paracancerous tissues outside 5cm beside the cancerous tissue of each patient were collected as control group. The positive rates of Survivin, Skp2 and XIAP mRNA in the two groups were compared, and the relationship between the expressions of Survivirh Skp2 and XIAP and clinicopathological features ofmRNA was analyzed. Results： The positive rates of Survivin, Skp2 and XIAP mRNA in the study group were significantly higher than those in the control group, and the difference was statistically significant （P〈0.05）. The positive expression of Survivin mRNA was not related to age, sex, tissue type, differentiation degree, clinical stage, lymph node metastasis and smoking history （P〉0.05）. The positive expression of Skp2 mRNA was not related to age, sex, tissue type, differentiation degree, lymph node metastasis and smoking history （P〉0.05）, but related to clinical stage （P〈0.05）. The positive expression of XIAP mRNA was not related to age, sex, tissue type, differentiation degree, smoking history （P〉0.05）, but related to clinical stage and lymph node metastasis （P〈0.05）. Conclusion： Survivin, Skp2 and XIAP mRNA are highly expressed in the pathological tissues of patients with NSCLC. The positive expression of Skp2 mRNA is related to the clinical stage, and the positive expression ofXIAP mRNA is related to the clinical stage and lymph node metastasis.
出处
《现代生物医学进展》
CAS
2017年第31期6159-6162,6200,共5页
Progress in Modern Biomedicine
