摘要
目的探讨宁心活血方治疗老年女性冠心病(CHD)的临床疗效及对病人血脂、血液流变学等实验室指标的影响。方法选择2015年3月—2016年5月在我院接受治疗的老年女性冠心病病人85例,根据其用药不同分为宁心活血方治疗组和西药治疗组。治疗1个月后,观察两组病人的临床疗效,比较两组病人治疗前后血脂[总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和三酰甘油(TG)]、血液流变学和心肌酶指标的差异。结果宁心活血方治疗组治疗有效率高于西药治疗组(χ~2=4.596,P=0.032)。治疗后,宁心活血方治疗组病人的TC、LDL-C和TG水平低于西药治疗组(t值分别为4.242、2.116、2.789,P<0.05);HDL-C水平高于西药治疗组(t=-4.519,P<0.001)。治疗后,宁心活血方治疗组病人的血浆黏度、全血黏度、血细胞比容和凝血因子水平均低于西药治疗组(t值分别为2.526、4.157、5.324、2.072,P=0.007、P<0.001、P<0.001、P=0.021)。治疗后,宁心活血方治疗组病人的肌酸激酶、肌酸激酶同工酶、N-末端B型脑钠肽前体(NT-proBNP)和肌钙蛋白I(CTnI)水平均低于西药治疗组(t值分别为11.489、4.815、58.169、18.546,P<0.001)。结论宁心活血方对老年女性冠心病病人有较好的临床效果,可明显改善病人的血脂、血液流变学指标。
Objective To investigate the effect of Ningxin Huoxue prescription （ NHP）on blood lipid,hemorheology and other labora -tory parameters in elderly female patient with coronary heart disease （ CHD） . Methods The elderly female patient with CHD wereselected in our hospital from March 2015 to May 2016,and divided into two groups：control group treated with western medicine rou -tine treatment, and treatment group treated with NHP for 1 month.The blood lipids,hemorheology indicators and enzymes were ob -served before and after treatment. Results The total clinical effective rate was significantly higher in treatment group than that incontrol group （ 97.4% vs 83.0%, χ2=4.596, P =0.032） . After treatment, the levels of total cholesterol,low density lipoprotein cho -lesterol, triglyceride in treatment group were lower than that in control group （ t =4.242, 2.116, 2.789, P 〈0.05） . The level of highdensity lipoprotein cholesterol in treatment group was higher than that in control group （ t = 4.519,P 〈0.001） . The levels of plas -ma viscosity, whole blood viscosity, hematocrit, and coagulation factors in treatment group were lower than that in control group （ t =2.526,P =0.007; t =4.157,P 〈0.001; t =5.324,P 〈0.001; t =2.072,P =0.021） . The levels of creatine kinase,isoenzyme ofcreatine kinase,N terminal pro brain nitric peptide, and cardiac troponin I in treatment group were lower than that in control group（ t =11.489, 4.815, 58.169, 18.546, P 〈0.001） . Conclusion NHP has a better therapeutic effect, and can significantly improve theblood lipids, and hemorheology indicators in elderly female patient with CHD.
作者
崔莹
Cui Ying(Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou 450000, Henan, Chin)
出处
《中西医结合心脑血管病杂志》
2017年第20期2525-2528,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
冠心病
中药
宁心活血方
血脂
心肌酶
血液流变学
coronary heart disease
Chinese medicine
Ningxin Huoxue prescription
blood lipid
enzymes
hemorheology
