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氯吡格雷对急性缺血性脑卒中患者血清炎性标志物的影响

Effect of Clopidogrel on Inflammatory Markers in Serum of Patients With Acute Ischemic Stroke
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摘要 目的分析氯吡格雷对急性缺血性脑卒中患者血清炎性标志物的影响。方法抽取2015年1月—2017年1月前来我院就诊的62例急性缺血性脑卒中患者,随机将其分为观察组和参照组各31例,两组患者在常规治疗的基础上,参照组选择阿司匹林进行治疗,观察组选用氯吡格雷,对比其临床疗效。结果观察组患者的血清炎性标志物指标均低于参照组,不良反应发生率观察组少于参照组(P<0.05),数据对比差异均有统计学意义。结论氯吡格雷治疗急性缺血性脑卒中患者其疗效显著,能有效控制病情,降低不良反应的发生率,提高治疗效果。 Objective To analyze the effect of clopidogrel on infammatory markers in serum of patients with acute ischemic stroke. Methods 62 patients with acute ischemic stroke were admitted in our hospital from January 2015 to January 2017, they were randomly divided into the observation group and the reference group, each with 31 cases, the two groups were treated on a routine basis, the reference group was treated with aspirin, the observation group was treated with clopidogrel, the clinical effcacy was compared. Results The serum infammatory markers in the observation group were lower than those in the reference group, the incidence of adverse reactions was fewer in the observation group than in the reference group (P 〈 0.05), the difference were statistically signifcant. Conclusion Clopidogrel is effective in the treatment of patients with acute ischemic stroke, can effectively control the condition, reduce the incidence of adverse reactions, improve treatment effect.
作者 李晨然
出处 《中国卫生标准管理》 2017年第24期74-75,共2页 China Health Standard Management
关键词 氯吡格雷 急性缺血性脑卒中 血清炎性标志物 阿司匹林 clopidogrel acute ischemic stroke serum inflammatory markers aspirin
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  • 1华先平,杜令,孔祥辉,管高峰,王琳.氯吡格雷对兔动脉粥样硬化血清高敏C-反应蛋白和血管壁核因子-κB表达的影响[J].实用医学杂志,2007,23(1):25-27. 被引量:15
  • 2Tanne D,Benderiy M,Goldbourt U,et al.C-reactive protein as a predictor of incident ischemic stroke among patients with preexisting cardiovascular disease[J].Srroke,2006,37(9):1720-1724. 被引量:1
  • 3Xiao Z,Theroux P.Clopidogrel inhibits platelet-leukocyte interactions and thrombin receptor agonist peptide-induced platelet activation in patients with an acute coronary syndrome[J].J Am Con Cardiol,2004,43(11):1982-1988. 被引量:1
  • 4Amarenco P, Labreuche J. Lipid management in the preventionof stroke : review and updated meta-analysjs of statins for strokeprevention[J]. Lancet Neurol, 2009 ( 8 ) : 453-463. 被引量:1
  • 5Corsini A. The safety of HMG-CoA reductase inhibitors inspecial populations at high cardiovascular risk [J]. Cardiol DrugTher, 2003, 17 ( 3 ): 265-285. 被引量:1
  • 6Lan WC, Waskell LA, Watkins PB, et al. Atorvastatin reduces the ability of clopidogrel to inhibit platelet aggregation : A new drug- drug interaction[J]. Circulation, 2003 ( 107 ) : 32-37. 被引量:1
  • 7Wang Y,Pan Y,Zhao X,et al.Clopidogrel with aspirin in acute minor stroke or transient ischemic attack(CHANCE):one-year outcomes[J].Circulation,2015,CIRCULATIONAHA.114.014791. 被引量:1
  • 8Manoj A L,Fitzsimmons P R,Sharma N,et al.Abstract T P344:clopidogrel resistance in stroke patients(The CRISP Trial)[J].Stroke,2014,45(1):344. 被引量:1
  • 9Lee M,Wu YL,Saver JL,et al.Abstract T MP107:Ischemic strokes while on aspirin:initiation of clopidogrel Is better than re-initiation of aspirin for prevention of future vascular events[J].Stroke,2014,45(1):107. 被引量:1
  • 10Shaban A,Rincon N,Tiu J,et al.Abstract W P59:safety and efficacy of acute clopidogrel load in patients with moderate and severe Ischemic strokes[J].Stroke,2015,46(1):59. 被引量:1

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