摘要
以苯肾上腺素为激动剂,在无钙K-H液中诱发大鼠去内皮主动脉环收缩并随后复钙的方法,观察粉防已碱和甲基莲心碱对主动脉环Ⅰ相收缩(胞内Ca^(++)释放)和Ⅱ相收缩(胞外Ca^(++)内流)的效应。结果表明,2×10^(-5)mol/L粉防己碱或甲基莲心碱预孵20min后,对Ⅰ、Ⅱ相的收缩均有非常明显的抑制作用(抑制率>92%,P<0.001);而短时预孵(5～10min)两药仅对Ⅲ相收缩有抑制作用,甲基莲心碱比粉防己碱起效慢、作用弱。
The effects of tetrandrine and neferine on the phenylephrine-induced contractions were studied in Sprague-Dawley rat aortic rings. It was found that both tetrandrine and neferine ( 2×10-5 mol/L ) markedly inhibited phase I ( release of intracellular calcium) and phase II (entry of extracellular calcium) contractions after a 20 min incubation. After a shorter incubation period, tetrandrine and nefrine inhibited only the phase II contractions. Compared with tetrandrine, neferine exhibited slower and weaker effects
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第5期357-359,共3页
Chinese Pharmacological Bulletin
基金
总后卫生部资助项目
关键词
粉防己碱
甲基莲心碱
主动脉环
Aortic rings
Phenylephrine
Tetrandrine
Neferine
