摘要
文章以聚乙二醇2000衍生化二硬脂酰磷脂酰乙醇胺(PEG2000-DSPE)为载体,采用薄膜分散法制备前列地尔(PGE1)胶束,评价其制剂学性质;并对其大鼠体内分布及金黄地鼠微循环血管药理作用进行研究。实验结果表明PGE1胶束在大鼠体内生物利用度和各组织含药量方面均高于PGE1注射剂;PGE1胶束对微血管作用强于PGE1注射剂,可显著降低血压、维持管径和血流速度并增强微血管自律运动。
In this paper, based on the PEG2000-DSPE as a carrier material, The prostaglandin micelles was pre-pared by films dlrtxibuted and study its pharmaceutics properties, biodistribution in rats and pharmacological action to microcirculation of hamsters. The experimental results show that the bioavailability and concentration in tissue of the prostaglandin micelles in rats was obvious higher than the common pharmaceutical preparations, its pharma-cological action to microcirculation was stronger, also the prostaglandin micelles could reduce blood pressure obvi-ously, maintain on the diameter and blood flow velocity and strengthen automatic rhythmicity in microvasculature.
作者
杨淼
YANG Miao(Xuzhou Medical University, Xuzhou Jiangsu 221004, China)
出处
《泰州职业技术学院学报》
2017年第5期39-42,共4页
Journal of Taizhou Polytechnic College
