摘要
为了提高药物灰黄霉素(GSV)的稳定性,静电纺制得载不同量GSV的醋酸纤维素(CA)/β-环糊精(β-CD)纳米纤维膜。采用扫描电镜(SEM)、傅里叶变换红外光谱(FT-IR)、X射线衍射(XRD)、紫外-可见光(UV-Vis)对载药纤维膜进行表征和分析,结果表明:随着载药量的增加,纤维直径变大,药物能完全包覆在纳米纤维内部,具有较高的热稳定性,药物缓释效果好。制得的醋纤基载药纳米纤维膜的纤维平均直径最高达507nm,经过72h后药物释放率最高达到80%。
To improve the stability of the drug griseofulvin（GSV）,the cellulose acetate（CA）/β-cyclodextrin（β-CD）nanofibers loaded with different molarmass of GSV were prepared by electrospinning.The morphologies and properties of nanofibers loaded with drugs were analyzed by SEM,spectra of FT-IR,XRD,DSC and ultraviolet light（UV-Vis）.The results showed that with the increase of drug,the fiber diameter became larger and the drug can be completely coated in the inside of nanofiber,with high thermal stability and good release effect.The average diameter of nanofibers was up to507 nm,and the drug release rate was up to 80% after 72 h.
作者
周建波
卢杭诣
张权
代雅轩
王清清
魏取福
Zhou Jianbo Lu Hangyi Zhang Quan Dai Yaxuan Wang Qingqing Wei Qufu(Key Laboratory of Eco-Textiles of Education,Jiangnan University,Wuxi 214122)
出处
《化工新型材料》
CAS
CSCD
北大核心
2017年第10期223-225,共3页
New Chemical Materials
基金
江苏省自然科学基金(BK20150155)
江苏省六大高峰人才项目(2014-XCL001)
关键词
醋酸纤维素
Β-环糊精
静电纺
药物缓释
cellulose acetate,β-cyclodextrin,electrospinning,drug release
