摘要
[目的]分析伽玛刀立体定向放射治疗原发性肝癌的疗效及预后因素。[方法]对66例原发性肝癌患者行伽玛刀治疗,以50%~70%的等剂量曲线覆盖95%的计划靶区,处方剂量3.8~6.0Gy/次,照射次数6~10次,肿瘤剂量30~60Gy,照射3次/周,隔日1次,总疗程2~3周。[结果]近期疗效总有效率(CR+PR)为80.3%(53/66),1、2、3年生存率分别为48.5%、24.2%、18.2%。Cox多因素分析显示肿瘤分期和肿瘤最大径是独立预后影响因素。[结论 ]伽玛刀治疗能有效改善原发性肝癌的肿瘤局部控制率和预后。
[Objective] To analyze the efficacy of Gamma-knife stereotactic body radiotherapy in treatment of patients with primary liver cancer（PLC）. [Methods] Sixty-six patients with primary liver cancer underwent Gamma-knife radiotherapy. During the procedure the 50% ~70% isodose line covered 95% of planning target volume. The radiotherapy regimen consisted of 30 ~60Gy in 6 ~10 fraction with 3.8 ~6.0Gy per fraction,the treatment was delivered 3 times per week during every other day. [Results] The response rate（CR＋PR） was 80.3%（53/66）,the overall 1-,2-and 3-year survival was 48.5%,24.2% and 18.2%,respectively. Multivariate Cox analysis showed that BCLC stage and tumor size were independent prognostic factors for patients. [Conclusion] Gamma knife radiotherapy for the treatment of primary liver cancer can effectively improve the local control rate and prognosis of patients.
出处
《肿瘤学杂志》
CAS
2017年第10期872-876,共5页
Journal of Chinese Oncology
关键词
肝肿瘤
放射疗法
伽玛刀
SBRT
预后
liver neoplasms
radiotherapy
Gamma-knife
SBRT
prognosis
