摘要
检验医学参考体系的建立是常规方法检测结果实现量值溯源的重要途径。完整的参考体系由参考测量程序、参考物质和参考实验室构成。参考测量程序通常为经过充分研究、具有较小的测量不确定度等特征。基于质谱技术在定量分析中的高特异性、高灵敏度的优势，其在检验医学参考测量程序的研究中发挥着重要作用，近40年来，越来越多的被应用于药物、电解质、代谢物和底物、非电解质金属元素、非肽激素、蛋白质和维生素的参考测量程序中，为这些已经明确定义的被测量的精准检测提供了有力保障。
The establishment of laboratory medicine reference system is an important way for routine detection results to achieve traceability. The complete reference system consists of reference measurement procedures, reference materials and reference laboratories. The reference measurement procedure is usually characterized by a thorough study with a small measurement uncertainty. Based on the advantages of high specificity and high sensitivity in quantitative analysis, mass spectrometry plays an important role in the research of the reference measurement procedures in laboratory medicine. In the past 40 years, mass spectrometry technology has been more and more widely applied in medicine, electrolytes, metabolites and substrates, non-electrolyte metals, non-peptide hormones, protein and vitamin. It provides a powerful guarantee for the precise detection of these well-defined measureds.（Chin J Lab Med, 2017, 40： 823-828）
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2017年第10期823-828,共6页
Chinese Journal of Laboratory Medicine
基金
上海市代谢性疾病（糖尿病）预防和诊治服务体系建设（GWIV-3）
上海市第四轮公共卫生三年行动计划重点学科建设卫生检验学（15GWZK0301）
关键词
参考值
参考标准
质谱分析法
Reference values
Reference standards
Mass spectrometry
