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肺癌CT多期增强扫描的影像学特征与特异性标记物表达相关性以及联合诊断价值研究 被引量:13

The correlation between CT imaging features and specific makers expression in lung cancer and evaluation of the diagnostic value of combined diagnosis
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摘要 目的探究肺癌患者的CT扫描影像学特征与血清C12多肿瘤特异性标记物的表达相关性以及两者联用的诊断价值。方法 2010年2月至2017年2月接受治疗的760例确诊原发性肺癌患者为研究对象并搜集其临床诊断资料,另选取500例健康体检者为对照组。对肺癌患者及正常人体血清中C12多肿瘤特异性标记物进行定量检测。按照瘤体直径分为大于5 cm的621例,不超过5 cm的139例;分为中央型肺癌344例和周围型肺癌416例;分为有坏死空洞征象的188例,无坏死空洞征象的572例;分为有毛刺征象的肺癌210例,无该征象的550例;有深分叶征象的肺癌249例,无深分叶征象的肺癌511例。以分析CT的影像学特征与该血清特异性标记物的表达相关性并评估联用诊断价值。结果肺癌组多肿瘤标记物中糖链抗原199(CA 199)、糖链抗原242(CA242)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、铁蛋白(Fe)、人绒毛膜促性腺激素(HCG)、甲胎蛋白(AFP)、癌抗原125(CA125)、癌抗原153(CA 153)的值显著高于对照组,两组差异有显著性(P<0.05);而两组间前列腺特异性抗原(PSA)、游离型前列腺特异性抗原(FPSA)和生长激素(HGH)的含量差异无显著性(P>0.05)。将肺癌患者根据CT影像学特征再分组比较C12多肿瘤特异性标记物水平,结果显示肿瘤大于5 cm患者与肿瘤不足5 cm的患者组间、有无坏死空洞组间、有无毛刺征象组间、有无深分叶征象组间差异均有显著性(P<0.05);而CT影像学特征中的不同病灶部位组间C12特异性标记物无显著差异(P>0.05)。结论肺癌CT多期增强扫描影像学特征中的肿瘤大小、有无坏死空洞、毛刺征象、深分叶征象与C12多肿瘤特异性标记物的表达有相关性,不同病灶部位则与特异性标记物表达无关。可将CT影像与特异性标记物联用,有利于更准确地诊断疾病。 Objective To investigate the correlation between CT imaging features and multiple tumormarkers expression in lung cancer and evaluation of the diagnostic value of combined diagnosis. Methods 760 patients diagnosed with lung cancer admitted in our hospital during the last 2 years were selected as lung cancer group then their clinical information were collected,and another 500 healthy volunteers were selected as control group. According to the diameter of the tumor,they were divided into more than 5 cm in 621 cases,not more than 5 cm of 139 cases;divided into 344 cases of central lung cancer and peripheral lung cancer 416 cases; divided into necrotic signs of 188 cases,no necrosis signs 572 cases were divided into burr signs of lung cancer 210 cases,no signs of 550 cases; deep lobular signs of lung cancer in 249 cases,no deep lobular signs of lung cancer 511 cases. The level of multiple tumor markers( including CA199,CA242,NSE,CEA,Fe,HCG,AFP,CA125,CA153,PSA,FPSA and HGH) were detected in two groups so as to analysis the correlation between CT imaging features and specific makers expression in lung cancer and evaluation the diagnostic value of combined diagnosis. Results The level of CA199,CA242,NSE,CEA,Fe,HCG,AFP,CA125 and CA153 in lung cancer group was significantly higher than control group,which showed statistical significance( P〈0. 05). But the level of PSA,FPSA and HGH between two groups showed no statistical significance( P〉0. 05). Then grouped of lung cancer patients by tumor size,lesion site,necrosis cavity,speculation and deep lobulation in lung cancer CT images,there were significant difference of multiple tumors markers between the groups with tumor larger/less than 5 cm,with/without necrosis cavity,with/without speculation and groups with/without deep lobulation( P〈0. 05). but the correlation of the group with cancer in different lesion site and multiple tumors markers showed no significant difference( P〉0. 05). Conclusion Tumor size,necrosis cavity,speculation and deep lobul
出处 《临床和实验医学杂志》 2017年第21期2140-2144,共5页 Journal of Clinical and Experimental Medicine
关键词 肺癌 CT影像学特征 多肿瘤特异性标记物 表达相关性 Lung cancer CT imaging feature C12 multiple tumor markers Expression correlation
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