摘要
目的:观察沙丁胺醇联合布地奈德雾化吸入对支气管哮喘的临床疗效。方法:选取217例支气管哮喘患者,将其按照随机数表法分为对照组108例和研究组109例。对照组给予吸氧、祛痰、氨茶碱静脉注射及抗生素抗感染等常规治疗,研究组在对照组治疗基础上给予布地奈德混悬液联合硫酸沙丁胺醇雾化吸入治疗,以7 d为1个疗程,连续治疗2个疗程。治疗后统计两组临床疗效,观察记录两组临床症状缓解时间,检测比较治疗前后两组肺功能指标的变化。结果:研究组临床总有效率为94.50%,显著高于对照组的71.30%(P<0.01);与对照组比较,研究组患者咳嗽消失时间、气促消失时间及肺部哮鸣音消失时间显著缩短(P<0.01);与治疗前比较,治疗后两组FEV1、PEF及研究组FVC均显著升高(P<0.01),且研究组均显著高于对照组(P<0.01)。结论:布地奈德混悬液联合硫酸沙丁胺醇雾化吸入治疗支气管哮喘的效果显著,其起效快,可改善患者临床症状及肺功能,疗效显著优于常规治疗。
Objective： To explore clinical efficacy of Salbutamol combined with Budesonide aerosol inhalation in treatment of bronchial asthma. Methods： 217 bronchial asthma patients were selected and divided randomly into control group（ n = 108） and study group（ n = 109） according to the random number table. The two groups were treated with the conventional therapy of oxygen uptake,making expectoration easy,and Aminophylline intravenous injection and antibiotic anti-infection; besides,the study group was treated with Budesonide mixed suspension combined with Salbutamol sulfate aerosol inhalation additionally,7 days as a course. The two groups were treated 2 courses continuously. The clinical efficacies of the two groups were statistically analyzed,the clinical symptoms remission time was recorded,and the changes of lung function indexes were compared. Results： The total clinical effective rate of the study group（ 94.50%） was significantly higher than that of the control group（ 71.30%）（ P〈0.01）.Compared with the control group,the cough,shortness of breath and lung wheezing sound disappeared times of the study group were shortened（ P〈0.01）. Compared with those before the treatment,the FEV1,and PEF of the two groups and FVC of the study group increased significantly（ P〈0.01）,and those of the study group were higher than those of the control group（ P〈0.01）. Conclusions： Budesonide mixed suspensioncombined with Salbutamol sulfate aerosol inhalation in the treatment of bronchial asthma is significantly effective,works fast and can improve the clinical symptoms and lung function. Moreover,its efficacy is superior to the conventional therapy significantly.
出处
《中国民康医学》
2017年第15期31-33,共3页
Medical Journal of Chinese People’s Health
