摘要
目的:观察喹硫平与曲唑酮应用于重度抑郁症患者的临床效果。方法:选取130例重度抑郁症患者作为研究对象,并通过随机数表法将入选患者分为对照组与研究组,每组65例,其中给予对照组患者盐酸曲唑酮片治疗,而研究组则在对照组的用药基础上添加喹硫平治疗;对两组患者的临床治疗效果进行观察与比较。结果:治疗后研究组总有效率(93.85%)高于对照组的总有效率(75.38%),研究组患者治疗后的汉密尔顿抑郁量表(Hamilton Depression Scale,HAMD)总评分改善情况明显优于对照组患者(P<0.05);研究组不良反应发生率(10.78%)与对照组的不良反应发生率(12.31%)比较差异无统计学意义(P>0.05)。结论:喹硫平与曲唑酮应用于重度抑郁症患者治疗中,临床效果明显,具有很高的应用价值。
Objective： To observe clinical effects of Quetiapine and Trazodone in treatment of patients with major depression.Methods： 130 patients with major depression were selected as the research objects and divided into control group（ n = 65） and study group（ n = 65） according to the random number table. The control group was treated with Trazodone hydrochloride tablets,while the study group was given Quetiapine combined with Trazodone hydrochloride tablets. The clinical effects of the two groups were observed and compared. Results： After the treatment,the total effective rate of the study group（ 93.85%） was higher than that of the control group（ 75.38%）,and the HAMD（ Hamilton depression scale） total score was better than that of control group（ P〈0.05）. Moreover,there was no statistical difference in the incidence of side effects between the control group（ 12.31%） and study group（ 10.78%）（ P〈0.05）. Conclusions： Quetiapine combined with Trazodone in the treatment of the patients with major depression has significant clinical effects and a high application value.
出处
《中国民康医学》
2017年第15期15-16,19,共3页
Medical Journal of Chinese People’s Health
关键词
喹硫平
曲唑酮
联合治疗
重度抑郁症
Quetiapine
Trazodone
Combination therapy
Major depression
