摘要
近些年的研究表明骨骼具有内分泌作用。负责骨形成的成骨细胞可分泌骨钙素调节能量代谢及男性生殖功能，其分泌的脂质运载蛋白2（lipocalin 2, LCN2）通过下丘脑影响摄食。作为高代谢活性细胞，成骨细胞在增殖、分化和矿化过程中需要葡萄糖和脂肪酸供给能量，其对葡萄糖和脂肪酸利用的改变能影响全身能量代谢的平衡。Wnt/β-catenin通路在骨形成中发挥着重要作用，通过基因编辑技术阻断或激活成骨细胞中Wnt/β-catenin通路可引起能量代谢失衡，且与Wnt/β-catenin通路密切相关的抗骨质疏松药物甲状旁腺激素和sclerostin单克隆抗体的应用与血糖、胰岛素敏感性、血脂和脂肪棕色化相关。尽管在该领域的研究已广泛开展，但仍有许多未知等待探索。
Skeleton has been proven to be an endocrine organ. Osteoblasts, the bone-forming cells in the skeleton, can secret osteocalcin which regulates global energy metabolism and male fertility in its undercarboxylated form and lipocalin 2 which influences appetite through binding to MC4R in the hypothalamus. Being a highly metabolic cell, osteoblast needs lots of energy through utilizing glucose and fatty acid to support its proliferation, differentiation, and mineralization. Recent data have shown the consumption change of fuels by osteoblasts, which contributes to global energy metabolism. Wnt/β-catenin signaling in osteoblasts is very important for bone formation, and disruption or constitutive activation of this pathway through gene editing may influence global energy metabolism. Through interacting with Wnt/β-catenin signaling, parathyroid hormone and sclerostin monoclonal antibody perform their anti-osteoporosis effect, and affect glucose homeostasis, insulin sensitivity, lipid metabolism and browning of peripheral adipose tissue. Though great progress has been made to understand the regulation of energy metabolism by bone during recent years, a lot of questions still remain to be answered.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2017年第10期811-815,共5页
Chinese Journal of Endocrinology and Metabolism
基金
国家自然科学基金项目（81300712）、教育部博士点基金（20130072120014）和上海市自然科学基金（13ZR1438000）
