摘要
软骨生长板(CGP)主要由软骨细胞及细胞外基质(ECM)构成。软骨细胞的增殖、分化、肥大及ECM的形成,是骨骼发育、线性生长的关键。因此,与CGP相关、调控生长的因素主要涉及作用于软骨细胞的生长激素-胰岛素样生长因子-1(GHIGF-1)轴、多种激素、旁分泌因子、炎性细胞因子等及软骨ECM中的胶原蛋白、非胶原糖蛋白、蛋白聚糖等成分。既往对调控生长的研究主要集中在GH-IGF-1轴上,但近年来,GH-IGF-1轴之外、CGP上可调控生长的其他相关因素备受关注。
Cartilage growth plate （CGP） is mainly composed of chondrocytes and extracellular matrix （ECM）. The proliferation, differentiation,hypertrophy of chondrocytes, and the formation of ECM, are the key to the development of bone and linear growth. Therefore,the factors related to CGP that regulation growth mainly include growth hormone-like insulin- like growth factor-1 （GH-IGF-1） axis, various hormones, paracrine factors and inflammatory cytokines acting on chondro- cytes and collagen in cartilage ECM, non-collagen glycoprotein, proteoglycan and other ingredients. Previous studies mostly focused on the regulation of GH-IGF-1 axis growth,but other relevant factors on CGP beyond GH-IGF-1 axis that can con- trol the growth receives more concern in recent years.
作者
王盼盼
邵倩
班博
WANG Pan-pan SHAO Qian BAN Bo(dining Medical University ,Jining,Shandong 272067 ,China Department of Endocrinology, Affiliated Hospital of dining Medical University ,dining,Shandong 272029 ,China)
出处
《中国儿童保健杂志》
CAS
2017年第11期1131-1133,共3页
Chinese Journal of Child Health Care
基金
山东省自然科学基金培养基金项目(ZR2014HP058)
关键词
生长板
软骨细胞
软骨细胞外基质
调控
生长
growth plate
ehondrocytes
extracellular matrix
regulation
growth
