摘要
目的丙型肝炎病毒(hepatitis C virus,HCV)患者常常伴随胰岛素抵抗以及糖尿病发生。本研究旨在探究慢性丙型肝炎(chronic hepatitis C,CHC)患者发生血糖异常的相关因素。方法本研究共纳入1 039名未经治疗的CHC患者。研究对象人口学资料、生化检查指标及其肝脏功能和HCV病毒载量等资料均来源于句容市人民医院传染科。结果有140名(13.5%)CHC患者被诊断为糖代谢异常。身体质量指数(x^2=9.231,P=0.010)、腰围(x^2=7.984,P=0.018)、收缩压(x^2=16.366,P<0.001)、舒张压(x^2=13.970,P=0.001)、丙氨酸转氨酶(alanine aminotransferase,ALT)(x^2=4.809,P=0.028)以及HCV-RNA载量(t=-3.818,P<0.001)等在CHC患者糖代谢正常与异常组间的分布差异具有统计学意义。多元回归分析发现,ALT(OR=2.986,95%CI:1.171~7.615)、HCV-RNA载量(OR=2.061,95%CI:1.165~3.644)为CHC患者合并糖代谢异常的危险因素。结论 ALT、HCVRNA载量可作为CHC患者糖代谢异常的提示因子,仍需对更多临床资料以及相关基因作进一步研究以发现CHC患者发生糖代谢异常新的危险因素。
Objective Hepatitis C virus patients are often accompanied by insulin resistance and diabetes.To probe the relative factors of abnormal glycometabolism in chronic HCV infections.Methods A total of 1 039 treatment-naive patients that were confirmed chronic HCV infected were enrolled in the study.The demographics,biochemical index parameters and other data about liver function and HCV viral load were got from infectious disease department of Jurong Pepole＇s Hospital in China.Results A total of 140 （13.5%） patients were diagnosed with some forms of abnormal glycometabolism.The body mass index （BMI） （x2 =9.231,P =0.010）,waist circumference （x2 =7.984,P =0.018）,systolic blood pressure （x2 =16.366,P 〈0.001）,diastolic blood pressure （x2 =13.970,P =0.001）,alanine aminotransferase（ALT） （x2 =4.809,P =0.028）,HCV-RNA viral load （t =-3.818,P 〈0.001） were significantly different between non-diabetic HCV patients and abnormal glycometabolism patients.Multivariate logistic regression analysis showed that ALT（OR =2.986,95% CI：1.171-7.615） and HCV-RNA viral load （OR =2.061,95% CI：1.165-3.644） were found as risk factors in multivariate regression analysis for patients with chronic hepatitis C who had abnormal glucose metabolism.Conclusions Chronic hepatitis C patients with higher ALT and HCV-RNA level were more probably to suffer from abnormal glycometabolism.In order to find potentially novel risk factors of HCV with abnormal glucose metabolisn,further studies about genetic and other clinical factors need to be processed.
作者
刘梅
臧凤
姚轶男
黄鹏
喻荣彬
LIU Mei;ZANG Feng;YAO Yi-nan;HUANG Peng;YU Rong-bin(Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China)
出处
《中华疾病控制杂志》
CAS
CSCD
北大核心
2017年第9期909-912,970,共5页
Chinese Journal of Disease Control & Prevention
基金
国家自然科学基金(81473029)
江苏高校优势学科建设工程资助(2014年)
关键词
胰岛素
血糖
肝炎
丙型
慢性
Insulin
Blood glucose
Hepatitis C,chronic
