摘要
目的研究丁酰胆碱酯酶活性以及急性心肌梗死患者预后之间的关系。方法将2012年1月至2017年1月本院收治的300例急性心肌梗死病例选为研究对象，依据丁酰胆碱酯酶活性差异分为低丁酰胆碱酯酶活性患者（A组，n=160）与高丁酰胆碱酯酶活性患者（B组，n=140）。比较2组预后及各项临床指标。结果2组吸烟史、性别组成、高血压、Killip分级以及HDL水平比较差异无统计学意义（P〉0．05）；A组年龄、血清肌酸酐、死亡率明显高于B组，且BMI、丁酰胆碱酯酶活性、收缩压、舒张压、血糖、LDL、甘油三酯、总胆固醇及LVEF明显低于B组（P〈0．05）。丁酰胆碱酯酶活性与年龄、血清肌酸酐呈负相关性，而与BMI、收缩压、舒张压、血糖、LDL、甘油三酯、总胆固醇及LVEF呈正相关性（P〈0．05）。死亡率升高独立影响因素主要为丁酰胆碱酯酶活性降低、LVEF减小。结论急性心肌梗死预后与丁酰胆碱酯酶活性存在相关性，患者死亡率升高主要独立因素包括丁酰胆碱酯酶活性，其测定可为患者治疗及预后提供一定指导。
Objective To study the relationship between the activity of cholinesterase and the prognosis of patients with acute myocardial infarction （AMI）. Methods A total of 300 cases of AMI admitted to our hospital from January 2012 to January 2017 were enrolled in the study. According to the activity of cholinesterase, they were divided into group A （patients with low activity of cholinesterase, n=160） and group B （patients with high activity of cholinesterase, n=140）. The prognosis and clinical indicators were compared between the two groups. Results There were no statistically significant differences between the two groups in smoking history, gender composition, hypertension, Killip grade, and HDL level （P〉0.05）. Age, serum creatinine, and mortality rate of group A were significantly higher than those of group B, BMI, systolic blood pressure, diastolic blood pressure, blood glucose, LDL, triglyceride, total cholesterol, and LVEF in group A were significantly lower than those in group B （P〈0.05）. The activity of cholinesterase was negatively correlated with age and serum creatinine, while was positively correlated with BMI, systolic blood pressure, diastolic blood pressure, blood glucose, LDL, triglyceride, total cholesterol, and LVEF （P〈0,05）. The main influencing factors of mortality were the decrease of the activity of cholinesterase and LVEF. Conclusion There is a correlation between the prognosis of AMI and the activity of cholinesterase. The main independent factor influencing mortality of patients is the activity of cholinesterase, and its determination can provide some guidance for the treatment of patients.
作者
常建航
Chang Jianhang(Department of Internal Medicine-Cardiovascular, The First People＇s Hospital of Pingdingshan City, Pingdingshan 467000, Chin)
出处
《国际医药卫生导报》
2017年第22期3503-3505,共3页
International Medicine and Health Guidance News
关键词
丁酰胆碱酯酶
急性心肌梗死
预后
关系
Cholinesterase
Acute myocardial infarction
Prognosis
Relationship
